876747-18-1

Usage

Uses

Used in Pharmaceutical Industry:
(2R)-2-Fluoropropan-1-ol 97% is used as a starting material for the synthesis of pharmaceuticals, as its unique structure with a fluorine atom attached to the second carbon of the propane chain can be utilized in the development of new drugs.
Used in Agrochemical Industry:
(2R)-2-Fluoropropan-1-ol 97% is used as a starting material for the synthesis of agrochemicals, as its specific structure can be employed in the creation of new pesticides or other agricultural chemicals.
Used in Specialty Chemicals Industry:
(2R)-2-Fluoropropan-1-ol 97% is used as a starting material for the synthesis of specialty chemicals, where its unique properties can be leveraged to produce compounds for specific applications.
Used in Chemical Research and Development:
(2R)-2-Fluoropropan-1-ol 97% is used as a research compound in chemical research and development, where its properties and reactivity can be studied and utilized to create new chemical processes or products.
Used in Industrial Product Production:
(2R)-2-Fluoropropan-1-ol 97% is used in the production of various industrial products, as its unique structure and properties can be employed in the manufacturing process to create innovative and improved products.

Upstream product

• 72959-94-5 (R)-(+)-ethyl 2-fluoropropionate 
• 146805-74-5 methyl (R)-2-fluoropropanoate 

Downstream Products

• 1140917-90-3 N-{(3E)-5-tert-butyl-1-methyl-2-[(2R)-tetrahydrofuran-2-ylmethyl]-1,2-dihydro-3H-pyrazol-3-ylidene}-2-{[(2R)-2-fluoropropyl]oxy}-5-(trifluoromethyl)benzamide 
• 790695-56-6 4-{[(2R)-2-fluoropropyl]oxy}-2-(trifluoromethyl)benzoic acid 

Relevant academic research and scientific papers

Practical selective hydrogenation of α-fluorinated esters with bifunctional pincer-type ruthenium(II) catalysts leading to fluorinated alcohols or fluoral hemiacetals

Selective hydrogenation of fluorinated esters with pincer-type bifunctional catalysts RuHCl(CO)(dpa) 1a, trans-RuH2(CO)(dpa) 1b, and trans-RuCl2(CO)(dpa) 1c under mild conditions proceeds rapidly to give the corresponding fluorinated alcohols or hemiacetals in good to excellent yields. Under the optimized conditions, the hydrogenation of chiral (R)-2-fluoropropionate proceeds smoothly to give the corresponding chiral alcohol without any serious decrease of the ee value.

METHOD FOR PRODUCING -FLUOROALCOHOL

A production method of a β-fluoroalcohol includes performing a reaction of an α-fluoroester with hydrogen gas (H2) in the presence of a specific ruthenium complex (i.e. a ruthenium complex of the general formula [2], preferably a ruthenium complex of the general formula [4]). This production method can employ a suitable hydrogen pressure of 1 MPa or less by the use of such a specific ruthenium complex and does not require a high-pressure gas production facility when put in industrial practice. In addition, this production method can remarkably reduce the amount of catalyst used therein (to e.g. a substrate/catalyst ratio of 20,000) in comparison to the substrate/catalyst ratio conventional reduction of α-fluoroalcohol. It is possible by these reduction in hydrogen pressure and catalyst amount to largely reduce the production cost of the β-fluoroalcohol.

DEHYDROXYLATED FLUORINATING AGENT

There is provided a novel, useful dehydroxyfluorination agent containing sulfuryl fluoride (SO2F2) and an organic base that is free from a free hydroxyl group in the molecule. According to the present dehydroxyfluorination agent, it is not necessary to use perfluoroalkanesulfonyl fluoride, which is not preferable in large-scale use, and it is possible to advantageously produce optically-active fluoro derivatives, which are important intermediates of medicines, agricultural chemicals and optical materials, for example, 4-fluoroproline derivatives, 2'-deoxy-2'-fluorouridine derivatives, optically-active α-fluorocarboxylate derivatives, and monofluoromethyl derivatives, even in large scale.

PROCES FOR PRODUCTION OF OPTICALLY ALPHA-FLUORO-CARBOXYLIC ESTER DERIVATIVES

The present invention relates to a process for producing an optically active α-fluorocarboxylate derivative represented by the formula [2], by reacting an optically active α-hydroxycarboxylate derivative with trifluoromethanesulfonyl fluoride (CF3SO2F) in the presence of an organic base, in the formula [2], R represents a straight-chain or branched-chain alkyl group of a carbon number of 1 to 12; one of or two by any combination of aromatic hydrocarbon groups, unsaturated hydrocarbon groups, straight-chain or branched alkoxy groups of a carbon number of 1 to 6, aryloxy groups, halogen atoms (fluorine, chlorine, bromine and iodine), protected carboxyl groups, protected amino groups or protected hydroxyl group can be substituted on any carbon atoms of the alkyl group; R1 represents a straight-chain or branched-chain alkyl group of a carbon number of 1 to 8; any carbon atoms of the alkyl groups of R and R1 may form a covalent bond; and * represents an asymmetric carbon.