876747-18-1

Basic information

• Product Name: (2R)-2-Fluoropropan-1-ol 97%
• Synonyms: (2R)-2-Fluoropropan-1-ol 97%;(2R)-2-Fluoro-1-hydroxypropane;(R)-2-Fluoro-1-propanol
• CAS NO: 876747-18-1
• Molecular Formula: C₃H₇FO
• Molecular Weight: 78.0854832
• Mol File: 876747-18-1.mol
• Article Data: 4

Chemical Properties

• Appearance: /
• CAS DataBase Reference: (2R)-2-Fluoropropan-1-ol 97%(CAS DataBase Reference)
• NIST Chemistry Reference: (2R)-2-Fluoropropan-1-ol 97%(876747-18-1)
• EPA Substance Registry System: (2R)-2-Fluoropropan-1-ol 97%(876747-18-1)

Safety Data

• Hazardous Substances Data: 876747-18-1(Hazardous Substances Data)

Usage

General Description

(2R)-2-Fluoropropan-1-ol is a chemical compound with a purity of 97%. It is an alcohol with a fluorine atom attached to the second carbon of the propane chain. (2R)-2-Fluoropropan-1-ol 97% can be used as a starting material for the synthesis of other organic compounds, including pharmaceuticals, agrochemicals, and specialty chemicals. It may also have applications in chemical research and development, as well as in the production of various industrial products. The 97% purity level indicates that the compound is relatively pure and suitable for various chemical reactions and processes. However, it is important to handle this chemical with care and follow proper safety protocols due to its potential hazards.

Upstream product

• 72959-94-5 (R)-(+)-ethyl 2-fluoropropionate 
• 146805-74-5 methyl (R)-2-fluoropropanoate 

Downstream Products

• 790695-56-6 4-{[(2R)-2-fluoropropyl]oxy}-2-(trifluoromethyl)benzoic acid 
• 1140917-90-3 N-{(3E)-5-tert-butyl-1-methyl-2-[(2R)-tetrahydrofuran-2-ylmethyl]-1,2-dihydro-3H-pyrazol-3-ylidene}-2-{[(2R)-2-fluoropropyl]oxy}-5-(trifluoromethyl)benzamide 

Relevant articles and documents

Practical selective hydrogenation of α-fluorinated esters with bifunctional pincer-type ruthenium(II) catalysts leading to fluorinated alcohols or fluoral hemiacetals

Selective hydrogenation of fluorinated esters with pincer-type bifunctional catalysts RuHCl(CO)(dpa) 1a, trans-RuH2(CO)(dpa) 1b, and trans-RuCl2(CO)(dpa) 1c under mild conditions proceeds rapidly to give the corresponding fluorinated alcohols or hemiacetals in good to excellent yields. Under the optimized conditions, the hydrogenation of chiral (R)-2-fluoropropionate proceeds smoothly to give the corresponding chiral alcohol without any serious decrease of the ee value.

DEHYDROXYLATED FLUORINATING AGENT

There is provided a novel, useful dehydroxyfluorination agent containing sulfuryl fluoride (SO2F2) and an organic base that is free from a free hydroxyl group in the molecule. According to the present dehydroxyfluorination agent, it is not necessary to use perfluoroalkanesulfonyl fluoride, which is not preferable in large-scale use, and it is possible to advantageously produce optically-active fluoro derivatives, which are important intermediates of medicines, agricultural chemicals and optical materials, for example, 4-fluoroproline derivatives, 2'-deoxy-2'-fluorouridine derivatives, optically-active α-fluorocarboxylate derivatives, and monofluoromethyl derivatives, even in large scale.