72959-94-5

Upstream product

• 63696-99-1 (S)-ethyl 2-(methylsulfonyloxy)propanoate 
• 687-47-8 (S)-Ethyl lactate 
• 94721-39-8 (R)-(+)-2-fluoro-2-methylmalonic acid monoethyl ester 
• 102712-69-6 (R)-(+)-ethyl 3-hydroxy-2-fluoropropionate 
• 685-88-1 fluoromalonic acid diethyl ester 
• 102712-70-9 (R)-2-Fluoro-3-(toluene-4-sulfonyloxy)-propionic acid ethyl ester 

Downstream Products

• 876747-18-1 (2R)-2-fluoropropanol 

Relevant academic research and scientific papers

Synthesis of the optically pure monoethyl ester of (R)-(+)-2-fluoromalonic acid by use of immobilized lipase-my for asymmetric hydrolysis

A synthetic approach to optically pure (+)-2-fluoromalonic acid monoethyl ester was based on the enantiotopic specificity of asymmetric hydrolysis by an immobilized enzyme. The absolute configuration of monoethyl (+)-2-fluoromalonate was determined : it is the (R)-enantiomer.

PROCESS FOR PREPARING 2-FLUOROPROPIONALDEHYDE

A process comprising (i) providing a 2-fluoropropionic acid halide; (ii) hydrogenating the 2-fluoropropionic acid halide by contacting it with a heterogeneous hydrogenation catalyst in an atmosphere comprising hydrogen, obtaining a mixture comprising 2-fluoropropionic aldehyde.

PROCESS FOR PRODUCING -SUBSTITUTED ESTER

There is provided a process for producing an α-substituted ester by reaction of a fluorosulfuric acid ester of α-hydroxyester with a Grignard reagent in the presence of a zinc catalyst. It is newly found that the reaction for production of α-substituted e

DEHYDROXYLATED FLUORINATING AGENT

There is provided a novel, useful dehydroxyfluorination agent containing sulfuryl fluoride (SO2F2) and an organic base that is free from a free hydroxyl group in the molecule. According to the present dehydroxyfluorination agent, it is not necessary to use perfluoroalkanesulfonyl fluoride, which is not preferable in large-scale use, and it is possible to advantageously produce optically-active fluoro derivatives, which are important intermediates of medicines, agricultural chemicals and optical materials, for example, 4-fluoroproline derivatives, 2'-deoxy-2'-fluorouridine derivatives, optically-active α-fluorocarboxylate derivatives, and monofluoromethyl derivatives, even in large scale.

PROCESS FOR THE MANUFACTURE OF FLUORINATED COMPOUNDS

A process for the manufacture of a fluorinated organic compound of formula R-F wherein R is an organic residue, which comprises reacting a starting material of general formula R-X wherein X is a leaving group with SO2F2. Addition of

PROCES FOR PRODUCTION OF OPTICALLY ALPHA-FLUORO-CARBOXYLIC ESTER DERIVATIVES

The present invention relates to a process for producing an optically active α-fluorocarboxylate derivative represented by the formula [2], by reacting an optically active α-hydroxycarboxylate derivative with trifluoromethanesulfonyl fluoride (CF3SO2F) in the presence of an organic base, in the formula [2], R represents a straight-chain or branched-chain alkyl group of a carbon number of 1 to 12; one of or two by any combination of aromatic hydrocarbon groups, unsaturated hydrocarbon groups, straight-chain or branched alkoxy groups of a carbon number of 1 to 6, aryloxy groups, halogen atoms (fluorine, chlorine, bromine and iodine), protected carboxyl groups, protected amino groups or protected hydroxyl group can be substituted on any carbon atoms of the alkyl group; R1 represents a straight-chain or branched-chain alkyl group of a carbon number of 1 to 8; any carbon atoms of the alkyl groups of R and R1 may form a covalent bond; and * represents an asymmetric carbon.

Titanium mediated asymmetric aldol reaction with α-fluoropropionimide enolates

Aldol reaction utilising Evans N-(α-fluoropropyl)-2-oxazolidinones with TiCl4 have been explored. Reactions of N-(α-fluoropropyl)-2-oxazolidinones with aliphatic aldehydes generated α-fluoro-β-hydroxy-aldol products with high diastereoselectivi

PROCESS FOR PRODUCTION OF FLUORO DERIVATIVE

A fluoro derivative can be produced by reacting a hydroxy derivative with sulfuryl fluoride (SO2F2) in the presence of an organic base or in the presence of an organic base and a salt or complex composed of an organic base and hydrogen fluoride. This process enables to advantageously produce an optically active fluoro derivative (e.g., a 4-fluoroproline derivative, a 2'-deoxy-2'-fluorouridine derivative and an optically active α-fluorocarboxylate ester derivative) which is an important intermediate for the production of a pharmaceutical or agricultural agent or an optical material, even in large quantity without using a perfluoroalkanesulfonyl fluoride which is undesirable for industrial applications.