87680-65-7Relevant articles and documents
A calcitriol synthesis of intermediates method
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Paragraph 0006, (2019/06/13)
The invention discloses a calcitriol intermediate compound preparation method, which belongs to the drug synthesis and organic compound synthesis technology field. The invention wide sources of raw materials are easy, simple and safe operation, environmen
A stereospecific synthesis of 24(S)-hydroxyvitamin D2, a prodrug for 1α,24(S)-dihydroxyvitamin D2
Coutts, Lisa D.,Geiss, William B.,Gregg, Brian T.,Helle, Mark A.,King, Chi-Hsin R.,Itov, Zinovy,Mateo, Mary E.,Meckler, Harold,Zettler, Mark W.,Knutson, Joyce C.
, p. 246 - 255 (2013/09/06)
This contribution describes the first stereospecific synthesis of 24(S)-hydroxyvitamin D2 (1), a metabolite of vitamin D2. This metabolite acts as a prodrug for 1α,24(S)-dihydroxyvitamin D2 (2), which is under development for treatment of various diseases characterized by cellular hyperproliferation. The key step of the synthesis involves the Wittig-Horner olefination of (S)-2,3-dimethyl-2-triethysilyloxybutyraldehyde (17) and a vitamin D2 phosphine oxide derivative (22). The synthesis of the requisite aldehyde started with the commercially available L-(+)-valine and was completed in seven steps. The vitamin D2 phosphine oxide derivative was synthesized in seven steps starting from vitamin D2.
An improved synthesis of 24,24-difluoro-1α,25-dihydroxyvitamin D3 from readily available vitamin D2
Ando,Koike,Takayama
, p. 189 - 192 (2007/10/02)
An improved synthesis of a highly potent vitamin D3 analog, 24,24-difluoro-1α,25-dihydroxyvitamin D3 (1b) has been accomplished via vitamin D2-SO2 adducts. The introduction of fluorine atoms was performed by tre