87682-62-0

Upstream product

• 69361-40-6 trimethyl(4-((tetrahydro-2H-pyran-2-yl)oxy)but-1-yn-1-yl)silane 
• 87682-77-7 (Z)-4-(trimethylsilyl)-but-3-en-1-ol 
• 98-59-9 p-toluenesulfonyl chloride 
• 2117-12-6 4-(trimethylsilyl)but-3-yn-1-ol 
• 122888-53-3 (Z)-4-(dimethyl(phenyl)silyl)but-3-en-1-ol 

Downstream Products

• 87682-61-9 N-(4-methoxybenzyl)-(Z)-4-(trimethylsilyl)-3-buten-1-ylamine 
• 109838-89-3 N-benzyl-(Z)-4-(trimethylsilyl)-3-buten-1-ylamine 
• 109838-90-6 N-benzyl-(E)-4-(trimethylsilyl)-3-buten-1-ylamine 
• 290333-63-0 (Z)-2-phenyl-2-(4-trimethylsilylbut-3-enylamino)ethanol 
• 133157-30-9 N-(4-methoxyphenyl)-(Z)-4-(trimethylsilyl)-3-buten-1-ylamine 
• 87682-66-4 N-cyclohexyl-N-(cyanomethyl)-(Z)-4-(trimethylsilyl)-3-buten-1-ylamine 
• 109720-57-2 2-[(4-Methoxy-benzyl)-((Z)-4-trimethylsilanyl-but-3-enyl)-amino]-4-phenyl-butyronitrile 
• 109720-59-4 [(4-Methoxy-benzyl)-((Z)-4-trimethylsilanyl-but-3-enyl)-amino]-pyridin-3-yl-acetonitrile 
• 109720-58-3 (3-Bromo-phenyl)-[propyl-((Z)-4-trimethylsilanyl-but-3-enyl)-amino]-acetonitrile 
• 109720-54-9 2-(N-(n-propyl)-<(Z)-4-(trimethylsilyl)-3-butenylamino>)-4-phenylbutanenitrile 
• 290333-65-2 (3S,5S)-5-Phenyl-3-phenylsulfanyl-4-((Z)-4-trimethylsilanyl-but-3-enyl)-2-trimethylsilanyloxy-morpholine 
• 290333-64-1 (Z)-5-phenyl-3-phenylsulfanyl-4-(4-trimethylsilylbut-3-enyl)morpholin-2-ol 
• 343565-23-1 benzyl (3R,5S)-5-acetoxymethyl-3-{[(Z)-1-trimethylsilyl-1-buten-4-yl]carbamoyl}piperidine-1-carboxylate 
• 343565-24-2 benzyl (3R,5S)-5-hydroxymethyl-3-{[(Z)-1-trimethylsilyl-1-buten-4-yl]carbamoyl}piperidine-1-carboxylate 

Relevant academic research and scientific papers

COMPOSITIONS AND METHODS FOR PARASITE CONTROL

The present invention relates in its broadest aspect to a compound of Formula I as provided herein, formulations comprising such a compound and corresponding uses thereof for the reduction of infestation with ectoparasites, in particular ectoparasites of the insect class, including fleas and mosquitoes and/or ectoparasites of the arachnid class, including ticks and mites, etc. Also provided herein are methods for preparing the formulations of the invention and methods for controlling ectoparasites using the compounds and/or formulations provided herein.

Synthesis of Azabicycles via Cascade Aza-Prins Reactions: Accessing the Indolizidine and Quinolizidine Cores

The first detailed studies of intramolecular aza-Prins and aza-silyl-Prins reactions, starting from acyclic materials, are reported. The methods allow rapid and flexible access toward an array of [6,5] and [6,6] aza-bicycles, which form the core skeletons of various alkaloids. On the basis of our findings on the aza-Prins and aza-silyl-Prins cyclizations, herein we present simple protocols for the intramolecular preparation of the azabicyclic cores of the indolizidines and quinolizidines using a one-pot cascade process of N-acyliminium ion formation followed by aza-Prins cyclization and either elimination or carbocation trapping. It is possible to introduce a range of different substituents into the heterocycles through a judicial choice of Lewis acid and solvent(s), with halo-, phenyl-, and amido-substituted azabicyclic products all being accessed through these highly diastereoselective processes.

Configuration-dependent ring opening of silyloxiranes: synthesis of functionalized alkenes or tetrahydrofurans

cis- and trans-Silyloxiranes with a potential tosylate or bromide leaving group in the β position are available by the diastereospecific reduction of the corresponding alkynes with DIBAL-H and hydrosilylation with silanes, respectively. In the reaction wi

The aza-silyl-Prins reaction: A novel method for the synthesis of trans-2,6-tetrahydropyridines

Reaction of 4-trimethylsilyl-3-butenyl-1-amines with aldehydes under mild Lewis acid conditions gives substituted tetrahydropyridines in excellent yields and with excellent trans diastereoselectivity.

A versatile indium trichloride mediated Prins-type reaction to unsaturated heterocycles

A versatile and high-yielding indium trichloride mediated cyclization reaction of silylated homoallylic alcohols, thiols, or amines with aldehydes or epoxides is described as a rapid route to a range of unsaturated heterocycles. The excellent diastereosel