876863-22-8

Upstream product

• 186581-53-3 diazomethane 
• 302842-81-5 (S)-α-(cyclopentyl-1-ene)-α-hydroxy-α-phenylacetic acic 
• 17199-29-0 (S)-Mandelic acid 
• 81036-97-7 (2S,5S)-2-tert-butyl-5-phenyl-1,3-dioxolan-4-one 
• 185030-08-4 cis-(2S,5S)-2-(tert-butyl)-5-phenyl-5-(cyclopentyl-1-ene)-1,3-dioxolan-4-one 
• 302842-80-4 (2S,5R)-2-(tert-butyl)-5-phenyl-5-(1-hydroxycyclopentyl)-1,3-dioxolan-4-one 

Relevant academic research and scientific papers

Stereoselective synthesis of the optical isomers of a new muscarinic receptor antagonist, quinuclidin-3-yl 2-(cyclopent-1-enyl)-2-hydroxy-2- phenylacetate

The enantiopure isomers of a new muscarinic receptor antagonist, quinuclidin-3-yl 2-(cyclopent-1-enyl)-2-hydroxy-2-phenylacetate were synthesised by a practical stereoselective synthetic method, using pivaldehyde as steric hindrance agent from the chiral starting material, (S) or (R)-mandelic acid. The isomers were obtained with 72-78% yields in 98-99% e.e.

Stereoselective synthesis of 3-azabicyclo[3,3,1]nonan-9α-yl α-(cyclopentyl-1-ene)-α-hydroxy-α-phenylacetate hydrochloride

The isomers of α-(cyclopentyl-1-ene)-α-hydroxy-α- phenylacetic acid esters derived from 3-azabicyclo[3,3,1]nonan-9α-ol ((R)-1 and (S)-1) were obtained in high enantiomeric excess by effective stereoselective synthesis from the chiral starting material, (S