877052-52-3

Upstream product

• 682746-13-0 (R)-7-(N-phenyl-aminooxy)-2,3-dioxa-spiro[4.5]decan-8-one 
• 877052-50-1 (7R,8S)-7,8-Bis-trimethylsilanyloxy-1,4-dioxa-spiro[4.5]decane-8-carbonitrile 
• 877052-51-2 (7R,8R)-7,8-Bis-trimethylsilanyloxy-1,4-dioxa-spiro[4.5]decane-8-carbaldehyde 
• 851764-31-3 (R)-4-hydroxy-1,4-dioxa-spiro[4.5]decan-8-one 

Downstream Products

• 103470-60-6 FR65814 
• 35903-52-7 fumagillol 
• 877052-55-6 Toluene-4-sulfonic acid (1R,2S,3S)-2-((E)-1,5-dimethyl-hexa-1,4-dienyl)-1,3-dihydroxy-4-oxo-cyclohexylmethyl ester 
• 877052-53-4 (1R,2R)-1-(tert-Butyl-dimethyl-silanyloxymethyl)-2-((E)-1,5-dimethyl-hexa-1,4-dienyl)-4-trimethylsilanyloxy-cyclohex-3-enol 
• 877052-54-5 (2S,3S,4R)-3-((E)-1,5-Dimethyl-hexa-1,4-dienyl)-2,4-dihydroxy-4-hydroxymethyl-cyclohexanone 

Relevant academic research and scientific papers

Concise enantio- and diastereoselective total syntheses of fumagillol, RK-805, FR65814, ovalicin, and 5-demethylovalicin

(Chemical Equation Presented) L-Proline-mediated α-aminoxylation is a key step in the enantio- and diastereoselective total syntheses of fumagillin, ovalicin, and related compounds (see scheme). These compounds contain a cyclohexane ring, two epoxides, an