877058-72-5Relevant articles and documents
Discovery of novel 2,3-diarylfuro[2,3-b]pyridin-4-amines as potent and selective inhibitors of Lck: Synthesis, SAR, and pharmacokinetic properties
Martin, Matthew W.,Newcomb, John,Nunes, Joseph J.,Bemis, Jean E.,McGowan, David C.,White, Ryan D.,Buchanan, John L.,DiMauro, Erin F.,Boucher, Christina,Faust, Theodore,Hsieh, Faye,Huang, Xin,Lee, Josie H.,Schneider, Stephen,Turci, Susan M.,Zhu, Xiaotian
, p. 2299 - 2304 (2008/02/02)
2,3-Diarylfuro[2,3-b]pyridine-4-amines are a novel class of potent and selective inhibitors of Lck. The discovery, synthesis, and structure activity relationships of this series of inhibitors are reported. The most promising compounds were also profiled t