877068-79-6Relevant academic research and scientific papers
Synthesis of 1-amino-2-vinylcyclopropane-1-phosphinates. Conversion of a phosphonate to phosphinates
Pyun, Hyung-Jung,Clarke, Michael O.,Cho, Aesop,Casarez, Anthony,Ji, Mingzhe,Fardis, Maria,Pastor, Richard,Sheng, X. Christopher,Kim, Choung U.
, p. 2360 - 2363 (2012/07/14)
Conversion of diethyl 1-amino-2-vinylcyclopropanephosphonate to ethyl 1-amino-2-vinylcyclopropanephosphinate was accomplished by using either nucleophilic or electrophilic carbon reagents. Hydrolysis of the phosphonate diethyl ester to the mono acid follo
Novel, potent, and orally bioavailable phosphinic acid inhibitors of the hepatitis C virus NS3 protease
Clarke, Michael O.,Chen, Xiaowu,Cho, Aesop,Delaney IV, William E.,Doerffler, Edward,Fardis, Maria,Ji, Mingzhe,Mertzman, Michael,Pakdaman, Rowchanak,Pyun, Hyun-Jun,Rowe, Tanisha,Yang, Cheng Y.,Sheng, X. Christopher,Kim, Choung U.
, p. 3568 - 3572 (2011/07/31)
A potent and novel class of product-like inhibitors of the HCV NS3 protease was discovered by employing a phosphinic acid as a carboxylate isostere. The replicon activity and pharmacokinetic profile of this series of compounds was optimized by exploring t
ANTIVIRAL PHOSPHINATE COMPOUNDS
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Page/Page column 86-87, (2008/06/13)
The invention is related to anti-viral phosphinate compounds, compositions containing such compounds, and therapeutic methods that include the administration of such compounds, as well as to processes and intermediates useful for preparing such compounds.
ANTIVIRAL COMPOUNDS
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Page/Page column 206-207, (2008/06/13)
The invention is related to phosphorus substituted anti-viral inhibitory compounds, compositions containing such compounds, and therapeutic methods that include the administration of such compounds, as well as to processes and intermediates useful for preparing such compounds.
