1314317-66-2Relevant academic research and scientific papers
Novel, potent, and orally bioavailable phosphinic acid inhibitors of the hepatitis C virus NS3 protease
Clarke, Michael O.,Chen, Xiaowu,Cho, Aesop,Delaney IV, William E.,Doerffler, Edward,Fardis, Maria,Ji, Mingzhe,Mertzman, Michael,Pakdaman, Rowchanak,Pyun, Hyun-Jun,Rowe, Tanisha,Yang, Cheng Y.,Sheng, X. Christopher,Kim, Choung U.
scheme or table, p. 3568 - 3572 (2011/07/31)
A potent and novel class of product-like inhibitors of the HCV NS3 protease was discovered by employing a phosphinic acid as a carboxylate isostere. The replicon activity and pharmacokinetic profile of this series of compounds was optimized by exploring t
ANTIVIRAL PHOSPHINATE COMPOUNDS
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Page/Page column 163-164, (2008/06/13)
The invention is related to anti-viral phosphinate compounds, compositions containing such compounds, and therapeutic methods that include the administration of such compounds, as well as to processes and intermediates useful for preparing such compounds.
