877079-66-8Relevant academic research and scientific papers
Synthesis and biological evaluation of allosteric A1-adenosine receptor modulators structurally related to (2-amino-4,5,6,7-tetrahydro-benzo[b] thiophen-3-yl)-(4-chloro-phenyl)-methanone, a potent compound useful to reduce neuropathic pain
Romagnoli, Romeo,Baraldi, Pier Giovanni,Pavani, Maria Giovanna,Tabrizi, Mojgan Aghazadeh,Iaconinoto, Maria Antonietta,Carrion, Maria Dora,Lopez Cara, Carlota,Shryock, John C.,Leung, Edward,Moorman, Allan R.,Gessi, Stefania,Merighi, Stefania,Borea, Pier Andrea
, p. 125 - 142 (2005)
New derivatives of (2-amino-4,5,6,7-tetrahydrobenzo[b]thiophen-3-yl)-(4- chlorophenyl)-methanone (compound 1), an allosteric enhancer of agonist binding to the A1-adenosine receptor, have been synthesized and evaluated in an intact cell assay a
New methodology for the N-alkylation of 2-amino-3-acylthiophenes
Aurelio, Luigi,Flynn, Bernard L.,Scammells, Peter J.
experimental part, p. 4886 - 4902 (2011/08/06)
2-Amino-3-acylthiophenes are known to allosterically modulate the A 1 adenosine receptor and are also used as intermediates in the synthesis of therapeutic agents and pharmacophores such as thienoazepines and thienopyrimidines. The N-alkylation
