87708-17-6Relevant academic research and scientific papers
Mild and safer preparative method for nonsymmetrical sulfamides via N-sulfamoyloxazolidinone derivatives: Electronic effects affect the transsulfamoylation reactivity
Borghese,Antoine,Van Hoeck,Mockel,Merschaert
, p. 770 - 775 (2012/12/22)
Sulfamides (R1R2N-SO2-NR3R 4) are traditionally prepared by using strong electrophilic and hazardous reagents such as N-sulfamoyl chloride, sulfonyl chloride, phosphorus oxychloride, or phosphorus pentachloride. We report here a safer and more convenient synthetic methodology for large-scale preparation of sulfamides using the N-substituted oxazolidin-2-one derivatives 5 as synthetic equivalent of the corrosive and hazardous N-sulfamoyl chloride. The scope of the use of N-sulfamoyloxazolidinones to prepare nonsymmetrical sulfamides is explored.
Derives de l'isocyanate de chlorosulfonyle. Synthese, structure et activite biologique d'halogeno-2 ethoxycarbonylsulfamides
Agoh, Bernadette,Dewynter, Georges,Montero, Jean-Louis,Leydet, Alain,Imbach, Jean-Louis
, p. 867 - 872 (2007/10/02)
New 2-chloroethoxycarbonylsulfamides are synthesized in a two step reaction from C.S.I., haloethanol and various primary and secondary amines.Cyclization of these sulfamides in basic medium gives the corresponding sulfamyl-oxazolidinones.All structures are established by IR, NMR, MS and RX diffraction data.The antitumor activity of the products towards LI210 is reported.
SELECTIVE SYNTHESIS OF SULFONYLUREAS AND CARBOXYSULFAMIDES. A NOVEL ROUTE TO OXAZOLIDINES.
Montero, Jean-Louis,Dewynter, Georges,Agoh, Bernadette,Delaunay, Barbara,Imbach, Jean-Louis
, p. 3091 - 3094 (2007/10/02)
Starting with chlorosulfonylisocyanate (CSI) two new series of 2-haloethyl carboxysulfamides 5 and 2-haloethyl oxosulfonylureas 6 have been prepared.The haloethyl carboxylate 5 underwent a novel cyclisation in the presence of Et3N to furnish quantitative
