87708-22-3

Upstream product

• 2483-57-0 methyl 2-nitroacetate 
• 104-88-1 4-chlorobenzaldehyde 
• 27895-56-3 [1-(4-Chloro-phenyl)-meth-(E)-ylidene]-isopropyl-amine 

Downstream Products

• 87708-26-7 methyl 6-chloro-2-methoxycarbonyl-α-(p-nitrobenzoyloxy)-1-oxido-3H-indole-3-acetate 
• 117617-32-0 (4R,5R)-4-(4-Chloro-phenyl)-4,5-dihydro-isoxazole-3,5-dicarboxylic acid dimethyl ester 

Relevant academic research and scientific papers

Highly diastereoselective condensation of α-nitro-esters with aldehydes catalyzed by zinc complexes of amino acids

Zinc complexes of amino acids efficiently catalyze the condensation between α-nitro-esters and a variety of aldehydes. An unusual domino reaction sequence leads to the diastereoselective formation of substituted isoxazoline N-oxides in high yields.

A Convenient One-Pot Synthesis of 4-Substituted 3,5-Bis(alkoxycarbonyl)-4,5-dihydroisoxazole 2-Oxides from Aldehydes and Nitroacetic Esters in a Solid-Liquid Reaction System and Subsequent Deoxygenation

4-Substituted 3,5-bis(alkoxycarbonyl)-4,5-dihydroisoxazole 2-oxides are obtained from nitroacetic esters and imines which are prepared from aldehydes and isopropylamine in the presence of molecular sieves.Reduction of the N-oxides with trimethyl phosphite