877121-64-7Relevant academic research and scientific papers
SAR study of bicyclo[4.1.0]heptanes as melanin-concentrating hormone receptor R1 antagonists: Taming hERG
Su, Jing,McKittrick, Brian A.,Tang, Haiqun,Burnett, Duane A.,Clader, John W.,Greenlee, William J.,Hawes, Brian E.,O'Neill, Kim,Spar, Brian,Weig, Blair,Kowalski, Timothy,Sorota, Steve,Li, Cheng,Liu, Tongtong
, p. 5369 - 5385 (2008/03/14)
To improve the ex vivo potency of MCH inhibitor 1a and to address its hERG liability, a structure-activity study was carried out, focusing on three regions of the lead structure. Introduction of new side chains with basic nitrogen improved in vitro and ex
NOVEL HETEROCYCLYLS AS SELECTIVE MELANIN CONCENTRATING HORMONE RECEPTOR ANTAGONISTS FOR THE TREATMENT OF OBESITY AND RELATED DISORDERS
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Page/Page column 31-32, (2008/06/13)
The present invention discloses compounds of formula I wherein m, n, p, R1, R2 and X, are herein defined, said compounds being novel antagonists for melanin-concentrating hormone (MCH), as well as methods for preparing such compounds
