877149-62-7

Basic information

• Product Name: 7-methyl-1-oxo-2-[4-(trifluoromethoxy)benzyl]-2,3-dihydro-1H-isoindole-5-carbonitrile
• Synonyms: 7-methyl-1-oxo-2-[4-(trifluoromethoxy)benzyl]-2,3-dihydro-1H-isoindole-5-carbonitrile
• CAS NO: 877149-62-7
• Molecular Weight: 346.309
• Mol File: 877149-62-7.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 7-methyl-1-oxo-2-[4-(trifluoromethoxy)benzyl]-2,3-dihydro-1H-isoindole-5-carbonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 7-methyl-1-oxo-2-[4-(trifluoromethoxy)benzyl]-2,3-dihydro-1H-isoindole-5-carbonitrile(877149-62-7)
• EPA Substance Registry System: 7-methyl-1-oxo-2-[4-(trifluoromethoxy)benzyl]-2,3-dihydro-1H-isoindole-5-carbonitrile(877149-62-7)

Safety Data

• Hazardous Substances Data: 877149-62-7(Hazardous Substances Data)

Upstream product

• 877149-28-5 5-bromo-7-methyl-2-[4-(trifluoromethoxy)benzyl]-2,3-dihydro-1H-isoindol-1-one 
• 143-33-9 sodium cyanide 
• 1314217-78-1 4-bromo-2-(hydroxymethyl)-6-methyl-N-[4-(trifluoromethoxy)benzyl]benzamide 
• 1314217-74-7 5-bromo-7-methyl-2-benzofuran-1(3H)-one 
• 206559-43-5 5-bromo-2-iodo-1,3-dimethyl-benzene 
• 74346-19-3 4-bromo-2,6-dimethylbenzoic acid 
• 557-21-1 zinc(II) cyanide 
• 557-21-1 dicyanozinc 

Downstream Products

• 877149-74-1 7-methyl-1-oxo-2-[4-(trifluoromethoxy)benzyl]-2,3-dihydro-1H-isoindole-5-carboxylic acid 
• 927210-23-9 tert-butyl 4-[(5-{7-methyl-1-oxo-2-[4-(trifluoromethoxy)benzyl]-2,3-dihydro-1H-isoindol-5-yl}-1,2,4-oxadiazol-3-yl)methyl]piperazine-1-carboxylate 
• 1314217-69-0 7-methyl-5-[(3-piperazin-1-ylmethyl)-1,2,4-oxadiazol-5-yl]-2-[4-(trifluoromethoxy)benzyl]-2,3-dihydro-1H-isoindol-1-one methanesulphonate 

Relevant articles and documents

Isoindolone formation via intramolecular Diels-Alder reaction

The intramolecular Diels-Alder reaction provides a useful synthetic methodology to build biologically active and synthetically useful isoindolone ring systems. An application of this methodology, providing an efficient manufacturing route to an mGluR2 positive allosteric modulator via a 1,5,7-substituted isoindolone, is reported herein.

ISOINDOLONE COMPOUNDS AND THEIR USE AS METABOTROPIC GLUTAMATE RECEPTOR POTENTIATORS

The present invention is directed to compounds of formula (I), wherein R1 is a ring and n is a number from 1 to 8. The invention also relates to use of the compounds in therapy as metabotropic glutamate receptor modulators, particularly in neurological and psychiatric disorders.