927210-23-9

Upstream product

• 1374160-80-1 C₂₀H₂₀F₃NO₅ 
• 1314358-28-5 ethyl 5-{[(4-trifluoromethoxybenzyl)amino]methyl}-furan-3-carboxylate 
• 1314217-86-1 ethyl 7-methyl-1-oxo-2-[4-(trifluoromethoxy)benzyl]-2,3-dihydro-1H-isoindole-5-carboxylate 
• 1040631-47-7 (Z)-tert-butyl 4-(2-amino-2-(hydroxyimino)ethyl)piperazine-1-carboxylate 
• 77290-31-4 tert-butyl 4-(cyanomethyl)piperazine-1-carboxylate 
• 1040631-47-7 4-(N-hydroxycarbamimidoylmethyl)piperazine-1-carboxylic acid tert-butyl ester 
• 1314217-84-9 ethyl 5-{[(4-trifluoromethoxybenzyl)amino]methyl}-furan-3-carboxylate hydrochloride 
• 1314217-78-1 4-bromo-2-(hydroxymethyl)-6-methyl-N-[4-(trifluoromethoxy)benzyl]benzamide 
• 1314217-74-7 5-bromo-7-methyl-2-benzofuran-1(3H)-one 
• 57260-71-6 1-t-Butoxycarbonylpiperazine 
• 877149-28-5 5-bromo-7-methyl-2-[4-(trifluoromethoxy)benzyl]-2,3-dihydro-1H-isoindol-1-one 
• 877149-74-1 7-methyl-1-oxo-2-[4-(trifluoromethoxy)benzyl]-2,3-dihydro-1H-isoindole-5-carboxylic acid 
• 877149-62-7 7-methyl-1-oxo-2-[4-(trifluoromethoxy)benzyl]-2,3-dihydro-1H-isoindole-5-carbonitrile 
• 206559-43-5 5-bromo-2-iodo-1,3-dimethyl-benzene 

Downstream Products

• 1092453-15-0 2,3-dihydro-7-methyl-5-[3-(1-piperazinylmethyl)-1,2,4-oxadiazol-5-yl]-2-[[4-(trifluoromethoxy)phenyl]methyl]-1H-isoindol-1-one 
• 1314217-69-0 7-methyl-5-[(3-piperazin-1-ylmethyl)-1,2,4-oxadiazol-5-yl]-2-[4-(trifluoromethoxy)benzyl]-2,3-dihydro-1H-isoindol-1-one methanesulphonate 

Relevant academic research and scientific papers

Isoindolone formation via intramolecular Diels-Alder reaction

The intramolecular Diels-Alder reaction provides a useful synthetic methodology to build biologically active and synthetically useful isoindolone ring systems. An application of this methodology, providing an efficient manufacturing route to an mGluR2 positive allosteric modulator via a 1,5,7-substituted isoindolone, is reported herein.

PROCESS FOR MAKING A METABOTROPIC GLUTAMATE RECEPTOR POSITIVE ALLOSTERIC MODULATOR - 874

Processes for making 7-methyl-5-(3piperazin-1-ylmethyl-[1,2,4]oxadiazol-5-yl)-2-(4- trifluoromethoxybenzyl)-2,3-dihydroisoindol-1-one

SUBSTITUTED ISOINDOLONES AND THEIR USE AS METABOTROPIC GLUTAMATE RECEPTOR POTENTIATORS

The present invention is directed to compounds of formula I: wherein R1, R2, R3, R4, R5, R6, R7, R8, R9 and n are as defined for formula I in the description. The invention also relates to processes for the preparation of the compounds and to new intermediates employed in the preparation, pharmaceutical compositions containing the compounds, and to the use of the compounds in therapy.

Oxadiazole Derivatives and Their Use as Metabotropic Glutamate Receptor Potentiators 842

Compounds of Formula I: wherein R1 and Q are as described in the specification, pharmaceutically-acceptable salts, methods of making, pharmaceutical compositions containing and methods for using the same.

SUBSTITUTED ISOINDOLONES AND THEIR USE AS METABOTROPIC GLUTAMATE RECEPTOR POTENTIATORS

The present invention is directed to compounds of formula (I), wherein R1 is a ring, R5 is a specified substituent, and n is from 1 to 8. The invention also relates to the use of the compounds in therapy as metabotropic glutamate receptors modulators, particularly in neurological and psychiatric disorders.