877169-81-8Relevant academic research and scientific papers
Pd-catalyzed dehydrogenative aryl-aryl bond formation via double C(sp2)-H bond activation: Efficient synthesis of [3,4]-fused oxindoles
Bunescu, Ala,Piou, Tiffany,Wang, Qian,Zhu, Jieping
, p. 334 - 337 (2015)
A Pd(0)-catalyzed double cyclization of easily available o-bromoanilides leading to strained [3,4]-fused oxindoles was developed. The reaction proceeded through a highly ordered sequence involving key carbopalladation, 1,4-Pd migration, and C(sp2)-H functionalization steps. (Chemical Equation Presented).
GUANIDINE DERIVATIVES AS TRPC MODULATORS
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Page/Page column 42-43, (2014/02/16)
The present invention is directed to guanidine derivatives as inhibitors of transient receptor potential canonical channels (TRPC channels), in particular TRPC3 and/or TRPC6 and/or TRPC7 activity, more particularly TRPC6 activity. Also provided herein are processes for preparing compounds described herein, intermediates used in their synthesis, pharmaceutical compositions thereof, and methods for treating or preventing diseases, conditions and/or disorders mediated by TRPC channels (Formula (I))
