877173-84-7 Usage
Uses
Used in Pharmaceutical Industry:
3-Bromo-7-chloropyrazolo[1,5-a]pyrimidine is used as a key intermediate in the synthesis of various pharmaceuticals. Its unique structure and chemical properties make it a versatile building block for the development of new drugs with potential therapeutic applications.
Used in Agrochemical Industry:
In the agrochemical industry, 3-Bromo-7-chloropyrazolo[1,5-a]pyrimidine is employed as an intermediate in the synthesis of agrochemicals. Its chemical properties and structure contribute to the development of new chemical entities with potential applications in crop protection and pest control.
Used in Organic Synthesis:
3-Bromo-7-chloropyrazolo[1,5-a]pyrimidine is used as a valuable building block in organic synthesis. Its unique structure allows for the creation of various chemical entities with different functional groups, making it a versatile compound for the synthesis of complex organic molecules.
Used in Drug Discovery:
3-Bromo-7-chloropyrazolo[1,5-a]pyrimidine is utilized in drug discovery as a starting material for the development of new chemical entities. Its unique chemical properties and structure make it an attractive candidate for the design and synthesis of novel drugs with potential therapeutic applications.
Used in Research and Development:
This chemical compound is an important tool for research and development in both the pharmaceutical and agricultural industries. It serves as a foundation for the exploration of new chemical pathways and the discovery of innovative solutions to various challenges in these fields.
Check Digit Verification of cas no
The CAS Registry Mumber 877173-84-7 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 8,7,7,1,7 and 3 respectively; the second part has 2 digits, 8 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 877173-84:
(8*8)+(7*7)+(6*7)+(5*1)+(4*7)+(3*3)+(2*8)+(1*4)=217
217 % 10 = 7
So 877173-84-7 is a valid CAS Registry Number.
InChI:InChI=1/C6H3BrClN3/c7-4-3-10-11-5(8)1-2-9-6(4)11/h1-3H
877173-84-7Relevant articles and documents
Novel Hinge-Binding Motifs for Janus Kinase 3 Inhibitors: A Comprehensive Structure-Activity Relationship Study on Tofacitinib Bioisosteres
Gehringer, Matthias,Forster, Michael,Pfaffenrot, Ellen,Bauer, Silke M.,Laufer, Stefan A.
, p. 2516 - 2527 (2015/08/24)
The Janus kinases (JAKs) are a family of cytosolic tyrosine kinases crucially involved in cytokine signaling. JAKs have been demonstrated to be valid targets in the treatment of inflammatory and myeloproliferative disorders, and two inhibitors, tofacitinib and ruxolitinib, recently received their marketing authorization. Despite this success, selectivity within the JAK family remains a major issue. Both approved compounds share a common 7H-pyrrolo[2,3-d]pyrimidine hinge binding motif, and little is known about modifications tolerated at this heterocyclic core. In the current study, a library of tofacitinib bioisosteres was prepared and tested against JAK3. The compounds possessed the tofacitinib piperidinyl side chain, whereas the hinge binding motif was replaced by a variety of heterocycles mimicking its pharmacophore. In view of the promising expectations obtained from molecular modeling, most of the compounds proved to be poorly active. However, strategies for restoring activity within this series of novel chemotypes were discovered and crucial structure-activity relationships were deduced. The compounds presented may serve as starting point for developing novel JAK inhibitors and as a valuable training set for in silico models.
PYRAZOLO[1,5-A] PYRIMIDINE COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
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Page/Page column 44-45, (2008/06/13)
The present invention relates to certain pyrazolo[1,5-a]pyrimidine compounds, to processes for their preparation, compositions comprising them and methods of using them. The compounds are useful in the treatment of cancer. Novel screening methods are also
