87719-17-3Relevant academic research and scientific papers
Synthesis and cancer cell cytotoxicity of gold(III) tetraarylporphyrins with a C5-carboxylate substituent
Liu, Jinliang,Chen, Huasheng,Li, Yan,Chen, Ying,Mao, Leilei,Xu, Aihua,Wang, Cunde
, p. 698 - 702 (2011)
Gold(III) tetraarylporphyrins with a C5-carboxylate substituent have been synthesised and their in vitro cytotoxic activity against SGC-7901 human gastric cancer cell line panel evaluated. The compound 5-[4-(4-ethoxycarbonylbut oxy)phenyl]-10,15,20-tri(4-
Magnetic Co(II) porphyrin nanospheres appending different substituent groups showing higher catalytic activities in cyclohexane
Zhao, Ping,Liu, Min-Chao,Zheng, Min,Jin, Shu-Fang,Tang, Ding-Tong,Lin, Jia-Qi,Ma, Yan-Na,Chen, Jiong,Liu, Hong-Jian
, p. 9843 - 9850 (2016/08/31)
Magnetic polymer nanospheres immobilizing Co(II) porphyrins with different substituents were prepared and exhibited satisfying size, morphology and magnetic responsiveness. These core/shell structured nanospheres showed much higher catalytic activities in hydroxylating cyclohexane than the non-supported Co(II) porphyrin analogues. Moreover, these magnetic nanospheres could be easily recovered and reused for up to five times with maintaining their high catalytic efficiencies, and thus are good candidates for high-efficient, environmental-friendly catalysts.
Novel phosphoramidates with porphine and nitrogenous drug: One-pot synthesis and orientation to cancer cells
Wang, Zhi-Wei,Guo, Can-Cheng,Xie, Wen-Zhong,Liu, Chao-Zhou,Xiao, Chun-Guang,Tan, Ze
experimental part, p. 890 - 895 (2010/04/29)
One-pot synthesis of novel phosphoramidates with porphine and nitrogenous drug was accomplished. In the absence of light, MTT test showed that they killed the BEL-7402 liver cancer cells effectively in vitro. The cell viability studied on normal liver and
Design, synthesis and biological evaluation of folate-porphyrin: A new photosensitizer for targeted photodynamic therapy
Li, Donghong,Diao, Junlin,Wang, Dong,Liu, Jianchang,Zhang, Jiaotao
experimental part, p. 547 - 555 (2011/03/20)
A novel folate-porphyrin conjugate 1 for targeted photodynamic therapy of tumor was designed and synthesized. The results of fluorescence spectroscopy and confocal laser scanning microscope demonstrated that the cellular uptake of conjugate 1 by HeLa cell
DNA Interactions with Porphyrins Bearing Ammonium Side Chains
Schneider, Hans-Joerg,Wang, Manxue
, p. 7473 - 7478 (2007/10/02)
Eleven new porphyrins bearing either tertiary amine or ammonium groups with different spacers in the meso position have been synthesized.Five of them were water-soluble enough for DNA binding studies.UV/vis measurements of some derivatives as a function of pH quantifies the porphyrin core protonation postulated recently by Marzilli et al. with an uptake of two protons and pK values of 6.0 or 6.4, respectively.The porphyrins as well as their Cu(II) or Zn(II) derivatives decrease the viscosity of ds(CT) DNA slightly and increase the melting point of DNA by only up to 1.7 deg C at DNA base pair/ligand ratios of 40.DNA causes either a red shift (/= -7 nm) of the Soret bands.These results as well as the observed small hypochromicities show that all new porphyrins interact with DNA without intercalation.However, their affinity in comparison with other macrocycles bearing four positive charges is, based on ethidium bromide assays with C50 values of 7E-8 to 2E-7 M relatively high and points to groove binding contributions by other than electrostatic forces.
