87719-37-7Relevant academic research and scientific papers
The Enantioselective Total Synthesis of Exochomine
Gao, Alison X.,Hamada, Tomoaki,Snyder, Scott A.
, p. 10301 - 10306 (2016)
Molecules that possess fully substituted chiral centers are often challenging to construct, particularly if those centers connect two seemingly different halves or include a nitrogen atom. Herein, we describe an efficient approach to a molecule that combines both challenges in a single center in the form of exochomine. Failures in direct coupling led to a design fueled by highly specific reaction conditions for several steps and the development of an improved protocol for 1,4-reduction in a hindered context where numerous side reactions were possible. These chemoselective solutions should have value to other problems. Challenges in obtaining matching spectral data for the synthesized natural product are also discussed.
Toward the synthesis of peloruside A: Fragment synthesis and coupling studies
Paterson, Ian,Di Francesco, M. Emilia,Kuehn, Toralf
, p. 599 - 602 (2007/10/03)
(Matrix presented). The asymmetric synthesis of building blocks 3, 4, and 5, corresponding to C12-C19, C7-C 11, and C1-C6 segments of peloruside A, is reported, along with boron-mediated al
