87741-94-4

Usage

Uses

Used in Pharmaceutical Industry:
2-Phenyl-6-hydroxyquinoline is used as an intermediate in the synthesis of pharmaceuticals for its potential therapeutic applications. Its unique structure allows it to be a key component in the development of new drugs.
Used as a pH Indicator:
2-Phenyl-6-hydroxyquinoline is used as a pH indicator due to its ability to change color in response to different pH levels, making it useful in various analytical and laboratory applications.
Used in Dye Synthesis:
In the dye industry, 2-Phenyl-6-hydroxyquinoline is used in the synthesis of dyes, capitalizing on its yellow crystalline solid form to create a range of colorants for various applications.
Used in Antimicrobial Applications:
Leveraging its antimicrobial properties, 2-Phenyl-6-hydroxyquinoline is used as an antimicrobial agent in different settings, such as in the development of antimicrobial coatings or in pharmaceuticals to combat infections.
Used in Anticancer Research:
2-Phenyl-6-hydroxyquinoline is used in anticancer research for its potential to target and inhibit the growth of cancer cells, offering a promising avenue for the development of new cancer treatments.

Upstream product

• 964-30-7 6-hydroxy-2-phenyl-quinoline-4-carboxylic acid 
• 111-34-2 -butyl vinyl ether 
• 588-53-4 N-benzylidene-p-hydroxyaniline 
• 4789-73-5 2-phenyl-6-methoxyquinoline 
• 32795-58-7 2-phenyl-6-methoxyquinoline-4-carboxylic acid 
• 42454-06-8 2-nitro-5-hydroxybenzaldehyde 
• 98-86-2 acetophenone 
• 13676-02-3 2-chloro-6-methoxyquinoline 

Relevant academic research and scientific papers

Amine compound for inhibiting SSASASASASASASAO/VAP-1 and application thereof in medicine (by machine translation)

The invention relates to an amine compound serving as an amino urea-sensitive amine oxidase (SSASAO) and/or a vascular adhesion protein -1 (VAP AP AP-1) inhibitor and application thereof in medicine, and further relates to a pharmaceutical composition containing the compound. The compounds or pharmaceutical compositions described herein may be used to treat inflammation and/or inflammation related diseases, diabetes and/or diabetes-related diseases, psychiatric disorders, ischemic diseases, vascular diseases, fibrosis or tissue transplant rejection. (by machine translation)

Inhibitors of the detoxifying enzyme of the phytoalexin brassinin based on quinoline and isoquinoline scaffolds

The detoxification of the phytoalexin brassinin to indole-3-carboxaldehyde and S-methyl dithiocarbamate is catalyzed by brassinin oxidase (BOLm), an inducible fungal enzyme produced by the plant pathogen Leptosphaeria maculans. Twenty-six substituted quinolines and isoquinolines are synthesized and evaluated for antifungal activity against L. maculans and inhibition of BOLm. Eleven compounds that inhibit BOLm activity are reported, of which 3-ethyl-6-phenylquinoline displays the highest inhibitory effect. In general, substituted 3-phenylquinolines show significantly higher inhibitory activities than the corresponding 2-phenylquinolines. Overall, these results indicate that the quinoline scaffold is a good lead to design paldoxins (phytoalexin detoxification inhibitors) that inhibit the detoxification of brassinin by L. maculans.

In vitro antifungal activity of polyfunctionalized 2-(hetero)arylquinolines prepared through imino Diels-Alder reactions

Diverse polyfunctionalized quinolines, easily prepared using Lewis acid-catalyzed imino Diels-Alder reactions between corresponding aldimines, were tested for antifungal properties against standardized as well as clinical isolates of clinically important fungi. Among them, 4-pyridyl derivatives displayed the best activities mainly against dermatophytes. The activity appears not to be related neither to the lipophilicity nor to the basicity of compounds.

Synthesis and study of 2-phenyl-5-nitrosoquinolin-6-ol and its iron(II) complex

2-Phenyl-5-nitrosoquinolin-6-ol and its iron(II) complex were prepared, and the dyeing properties of the latter were studied.

DDQ-mediated formation of carbon-carbon bonds: Oxidation of imines

The reaction of imines with alkynes and alkenes, in the presence of 2,3-dichloro-5,6-dicyano-p-benzoquinone (DDQ), to give quinoline derivatives is described. The mechanism of the annulation is discussed, and evidence supporting a non-concerted pathway, at least when the alkene is butyl vinyl ether, is reported. Preliminary information is also given about solid adducts of imines with DDQ, which do not seem to be involved in the reaction path leading to quinolines, and should account for the dependence of product yields on the position of substituents on the starting imines.