87745-17-3 Usage
Uses
Used in Pharmaceutical Research:
2-(PROPYL-1,1-D2)PENTANOIC-3,3-D2 ACID is used as a labeled analogue for Valproic Acid in pharmaceutical research. It aids in understanding the metabolic pathways and enzyme mechanisms involved in the action of Valproic Acid, an antiepileptic and mood stabilizer for bipolar disorder.
Used in Metabolic Studies:
In metabolic studies, 2-(PROPYL-1,1-D2)PENTANOIC-3,3-D2 ACID serves as a valuable tool for tracking the metabolic fate of Valproic Acid in biological systems. The incorporation of deuterium atoms allows for the differentiation between the endogenous and administered compounds, providing insights into the metabolic processes.
Used in Enzyme Mechanism Studies:
2-(PROPYL-1,1-D2)PENTANOIC-3,3-D2 ACID is utilized in enzyme mechanism studies to investigate the role of Valproic Acid in various enzymatic reactions. The presence of deuterium atoms can provide information on the reaction kinetics and the involvement of specific amino acid residues in the enzyme active site.
Used in Drug Development:
In drug development, 2-(PROPYL-1,1-D2)PENTANOIC-3,3-D2 ACID can be employed to evaluate the potential of Valproic Acid as a lead compound for the development of new therapeutic agents. The deuterated analogue can help in assessing the structure-activity relationship and optimizing the pharmacological properties of the compound.
Used in Analytical Chemistry:
2-(PROPYL-1,1-D2)PENTANOIC-3,3-D2 ACID is used as an internal standard in analytical chemistry for the quantification of Valproic Acid in various samples, such as biological fluids and pharmaceutical formulations. The presence of deuterium atoms provides a distinct mass signature, allowing for accurate and precise measurements.
Check Digit Verification of cas no
The CAS Registry Mumber 87745-17-3 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 8,7,7,4 and 5 respectively; the second part has 2 digits, 1 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 87745-17:
(7*8)+(6*7)+(5*7)+(4*4)+(3*5)+(2*1)+(1*7)=173
173 % 10 = 3
So 87745-17-3 is a valid CAS Registry Number.
87745-17-3Relevant academic research and scientific papers
beta-deuterated valproic acid preparation method
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Paragraph 0055; 0061-0063, (2018/07/30)
The invention discloses a beta-deuterated valproic acid preparation method, which sequentially comprises: carrying out an intramolecular valproyl carbon skeleton beta-site directed deuteration reaction on 8-aminoquinoline valpromide in D2O by using palladium acetate as a catalyst to generate deuterated 8-aminoquinoline valpromide, wherein the deuteration reaction is performed in a sealed state; and carrying out a hydrolysis reaction on the deuterated 8-aminoquinoline valpromide in an organic solvent under the action of an alkali under a normal pressure reflux condition, and carrying out acidification treatment to obtain beta-deuterated valproic acid. According to the present invention, the method has advantages of high selectivity, simple reaction post-treatment, easily available raw materials and environmental protection, and provides the efficient and accurate method for the efficient synthesis of beta-deuterated valproic acid.
Mild and Direct Multiple Deuterium-Labeling of Saturated Fatty Acids
Yamada, Tsuyoshi,Park, Kwihwan,Yasukawa, Naoki,Morita, Kosuke,Monguchi, Yasunari,Sawama, Yoshinari,Sajiki, Hironao
supporting information, p. 3277 - 3282 (2016/10/21)
We have established a mild and direct platinum on carbon (Pt/C)-catalyzed multi-deuterium labeling of various saturated fatty acids including bioactive compounds with high deuterium efficiencies in a mixed solvent of isopropyl alcohol and deuterium oxide
