261956-22-3 Usage
Uses
Used in Pharmaceutical Industry:
Ro28-2653 is used as an anti-invasive agent for its ability to inhibit the invasiveness of cancer cells, potentially limiting their spread to other tissues and organs.
Ro28-2653 is used as an antitumoral agent for its capacity to impede the growth and progression of tumors, making it a potential therapeutic option for cancer treatment.
Ro28-2653 is used as an antiangiogenic agent for its ability to prevent the formation of new blood vessels that supply nutrients to tumors, thereby starving them of essential resources for growth and survival.
Ro28-2653 is used as a matrix metalloproteinases (MMPs) inhibitor for its selective inhibition of MMPs, which are enzymes involved in the breakdown of extracellular matrix proteins. This property makes it a valuable tool in the development of targeted therapies for various diseases, including cancer.
Check Digit Verification of cas no
The CAS Registry Mumber 261956-22-3 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,6,1,9,5 and 6 respectively; the second part has 2 digits, 2 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 261956-22:
(8*2)+(7*6)+(6*1)+(5*9)+(4*5)+(3*6)+(2*2)+(1*2)=153
153 % 10 = 3
So 261956-22-3 is a valid CAS Registry Number.
261956-22-3Relevant academic research and scientific papers
Daniewski, Andrzej R.,Liu, Wen,Okabe, Masami
, p. 411 - 414 (2004)
An efficient synthesis of Ro 28-2653, a selective matrix metalloproteinase inhibitor, has been developed. The title compound was prepared in four steps and 76% overall yield from 4-biphenylacetic acid. The key, barbituric acid formation step was significantly improved by using 2-propanol and potassium tert-butoxide as the solvent and base, respectively, instead of the typical ethanol and sodium ethoxide combination.
