877593-11-8Relevant articles and documents
Azaindole synthesis through dual activation catalysis with N-heterocyclic carbenes
Sharma, Hayden A.,Todd Hovey,Scheidt, Karl A.
, p. 9283 - 9286 (2016/07/25)
A convergent, transition-metal-free synthesis of 2-aryl-azaindoles has been developed. The interception of a reactive aza-ortho-azaquinone methide intermediate by an acyl anion equivalent generated through carbene catalysis provides high yields, a wide substrate scope, and the synthesis of previously inaccessible azaindoles.
SUBSTITUTED HETEROCYCLES AND THEIR USE AS CHK1, PDK1 AND PAK INHIBITORS
-
Page/Page column 129-130, (2008/06/13)
This invention relates to novel compounds of Formula (I) and to their pharmaceutical compositions and to their methods of use. These novel compounds possess CHK1 kinase inhibitory activity, PDK1 inhibitory activity and Pak kinase inhibitory activity and are accordingly useful in the treatment and/or prophylaxis of cancer.
Preparation and chemical behavior of 2-(tert-butoxycarbonyl)amino-3- bromomethyl pyridine, a novel alkylating agent
Krasavin, Mikhail,Shkavrov, Sergey,Kravchenko, Dmitry
, p. 181 - 186 (2007/10/03)
Synthesis of a novel heterocyclic alkylating agent has been developed. Its instability toward elevated temperatures and/or polar media can be used to prepare 8-aza-1,4-dihydrobenzo[1,3-d]oxazin-2-one. Copyright Taylor & Francis LLC.