877608-37-2Relevant academic research and scientific papers
A highly efficient method for solvent-free synthesis of bisarylmethylidenes of pyranones and thiopyranones
Abaee, M. Saeed,Mojtahedi, Mohammad M.,Zahedi, M. Mehdi,Sharifi, Roholah
, p. 44 - 49 (2007)
A remarkable efficient double crossed aldol condensation of heterocyclic ketones with a variety of aromatic aldehydes is described at room temperature in the presence of magnesium bromide ethyl etherate, triethylamine, and methanol under solvent-free cond
A Diarylpentanoid with Potential Activation of the p53 Pathway: Combination of in silico Screening Studies, Synthesis, and Biological Activity Evaluation
Moreira, Joana,Almeida, Joana,Loureiro, Joana B.,Ramos, Helena,Palmeira, Andreia,Pinto, Madalena M.,Saraiva, Lucília,Cidade, Honorina
supporting information, p. 2969 - 2981 (2021/07/28)
In silico studies of a library of diarylpentanoids led us to the identification of potential new MDM2/X ligands. The diarylpentanoids with the best docking scores obeying the druglikeness and ADMET prediction properties were subsequently synthesized and e
New MD2 inhibitors derived from curcumin with improved anti-inflammatory activity
Zhang, Yali,Liu, Zhiguo,Wu, Jianzhang,Bai, Bin,Chen, Hongjin,Xiao, Zhongxiang,Chen, Lingfeng,Zhao, Yunjie,Lum, Hazel,Wang, Yi,Zhang, Hong,Liang, Guang
, p. 291 - 305 (2018/02/21)
An overactive Toll-like receptor (TLR) signaling complex is a significant pathogenic factor of acute and chronic inflammatory diseases. The natural product curcumin is reported to inhibit the TLR4 co-receptor, MD2 (myeloid differentiation protein 2), but
CURCUMIN ANALOGS AND METHODS OF USE THEREOF
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Page/Page column 20; 25, (2012/03/09)
Curcumin analogs and methods of use thereof are provided.
Synthesis and evaluation of curcumin-related compounds for anticancer activity
Wei, Xingchuan,Du, Zhi-Yun,Zheng, Xi,Cui, Xiao-Xing,Conney, Allan H.,Zhang, Kun
experimental part, p. 235 - 245 (2012/08/28)
Sixty-one curcumin-related compounds were synthesized and evaluated for their anticancer activity toward cultured prostate cancer PC-3 cells, pancreas cancer Panc-1 cells and colon cancer HT-29 cells. Inhibitory effects of these compounds on the growth of PC-3, Panc-1 and HT-29 cells were determined by the MTT assay. Compounds E10, F10, FN1 and FN2 exhibited exceptionally potent inhibitory effects on the growth of cultured PC-3, Panc-1 and HT-29 cells. The IC50 for these compounds was lower than 1 μM in all three cell lines. E10 was 72-, 46- and 117-fold more active than curcumin for inhibiting the growth of PC-3, Panc-1 and HT-29 cells, respectively. F10 was 69-, 34- and 72-fold more active than curcumin for inhibiting the growth of PC-3, Panc-1 and HT-29 cells, respectively. FN1 and FN2 had about the same inhibitory effect as E10 and F10 toward Panc-1 cells but were less active than E10 and F10 toward PC-3 and HT-29 cells. The active compounds were potent stimulators of apoptosis. The present study indicates that E10, F10, FN1 and FN2 may have useful anticancer activity.
The synthesis of highly functionalised pyridines using Ghosez-type reactions of dihydropyrazoles
Catti, Federica,Kiuru, Paula S.,Slawin, Alexandra M.Z.,Westwood, Nicholas J.
, p. 9561 - 9566 (2008/12/22)
The aza-Diels-Alder reaction of αβ-unsaturated hydrazones is a general methodology that has been applied both to the synthesis of natural products and to the development of multicomponent reactions. Trends have emerged as to the effect of substituents on the efficiency of this reaction with substituents at the C2 and C4-positions of the aza-diene in general suppressing the reaction. Here we report that 4,5-dihydropyrazoles can function as substrates in this process despite the presence of substituents at both of these positions. A one pot, four chemical step sequence carried out under standard thermal or microwave conditions results in the formation of the corresponding pyridine-containing compounds. The scope of the reaction is explored and additional insights into the proposed mechanism of this reaction are provided.
