87770-49-8

Upstream product

• 13099-95-1 ethyl 2,3-dihydro-3-oxo-benzofuran-2-carboxylate 
• 87770-64-7 2-carbethoxy-3-methoxybenzofuran 
• 74812-72-9 3-methoxybenzofuran-2-carbohydrazide 
• 2284-20-0 4-Methoxyphenyl isothiocyanate 

Downstream Products

• 87770-61-4 2-(5'-p-anisylamino-1',3',4'-thiadiazol-2'-yl)-3-methoxybenzofuran 
• 87770-55-6 3-methoxy-2-(4'-p-anisyl-3'-mercapto-1',2',4'-triazol-5'-yl)benzofuran 

Relevant academic research and scientific papers

Studies in Benzofurans: Part XIII - Synthesis of Substituted 1,3,4-Oxadiazolyl-, Thiadiazolyl- and 1,2,4-Triazolyl-benzofurans

3-Methoxybenzofuran-2-carbohydrazide (3), obtained from 2-carbethoxy-3-methoxybenzofuran (2), undergoes condensation isothiocyanates to furnish the corresponding thiosemicarbazides (4).Cyclisation of 4 in the presence of alkali furnishes the corresponding 2-(3'-mercapto-1',2',4'-triazol-5'-yl)-3-methoxybenzofurans (5).However, in presence of anhyd. orthophosphoric acid 4a-e yield 2-(5'-amino-1',3',4'-thiadiazol-2'-yl)-3-methoxybenzofurans (6a-e).Conversion of 3 into 3-methoxy-2-(1',3',4'-oxadiazol-2'-yl)-benzofuran (10) and its 5'-mercapto derivative (7) has also been carried out.