87770-61-4Relevant academic research and scientific papers
Studies in Benzofurans: Part XIII - Synthesis of Substituted 1,3,4-Oxadiazolyl-, Thiadiazolyl- and 1,2,4-Triazolyl-benzofurans
Basavaraja, K. M.,Agasimundin, Y. S.
, p. 458 - 461 (2007/10/02)
3-Methoxybenzofuran-2-carbohydrazide (3), obtained from 2-carbethoxy-3-methoxybenzofuran (2), undergoes condensation isothiocyanates to furnish the corresponding thiosemicarbazides (4).Cyclisation of 4 in the presence of alkali furnishes the corresponding 2-(3'-mercapto-1',2',4'-triazol-5'-yl)-3-methoxybenzofurans (5).However, in presence of anhyd. orthophosphoric acid 4a-e yield 2-(5'-amino-1',3',4'-thiadiazol-2'-yl)-3-methoxybenzofurans (6a-e).Conversion of 3 into 3-methoxy-2-(1',3',4'-oxadiazol-2'-yl)-benzofuran (10) and its 5'-mercapto derivative (7) has also been carried out.
