87782-49-8 Usage
General Description
1-(2-deoxy-(2-fluoroarabinofuranosyl))-5-vinyluracil, also known as FdU, is a synthetic nucleoside analogue that has been studied for its potential antitumor effects. It is a fluorinated derivative of the nucleoside uracil, and its structure includes a deoxyribose sugar molecule linked to a fluoroarabinofuranosyl group and a vinyl group. FdU is designed to disrupt the replication and transcription processes of DNA and RNA, which are essential for cell proliferation and survival. The compound has shown promising results in inhibiting the growth of various cancer cell lines in preclinical studies, and it is being investigated for its potential use in cancer therapy. Additionally, FdU has also been studied for its antiviral properties, particularly in the context of treating infections caused by herpes simplex virus.
Check Digit Verification of cas no
The CAS Registry Mumber 87782-49-8 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 8,7,7,8 and 2 respectively; the second part has 2 digits, 4 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 87782-49:
(7*8)+(6*7)+(5*7)+(4*8)+(3*2)+(2*4)+(1*9)=188
188 % 10 = 8
So 87782-49-8 is a valid CAS Registry Number.
InChI:InChI=1/C11H13FN2O5/c1-2-5-3-14(11(18)13-9(5)17)10-7(12)8(16)6(4-15)19-10/h2-3,6-8,10,15-16H,1,4H2,(H,13,17,18)/t6-,7+,8-,10-/m1/s1
87782-49-8Relevant articles and documents
Nucleosides. 129. Synthesis of antiviral nucleosides: 5-alkenyl-1-(2-deoxy-2-fluoro-beta-D-arabinofuranosyl)uracils.
Watanabe,Su,Reichman,Greenberg,Lopez,Fox
, p. 91 - 94 (1984)
Synthesis of 1-(2-deoxy-2-fluoro-beta-D-arabinofuranosyl)uracils containing a vinyl (4a), 2-halovinyl (4b-d), or ethyl substituent at C-5 was achieved. These nucleosides were found to be about a log order less active than 2'-fluoro-5-iodo-ara-C (FIAC) aga
