877861-68-2Relevant academic research and scientific papers
COMPOUND CONTAINING BASIC GROUP AND USE THEREOF
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, (2008/06/13)
The present invention relates to a compound represented by formula (I-0): wherein symbols in formula have the same meanings as described in the present specification, a salt thereof, an N-oxide thereof or a solvate thereof or a prodrug thereof, and medical use thereof The compound of the present invention has an antagonistic activity against CXCR4 and is therefore useful as a preventive and/or therapeutic agent for CXCR4-mediated diseases, for example, inflammatory and immune diseases (for example, rheumatoid arthritis, arthritis, retinopathy, pulmonary fibrosis, transplanted organ rejection, etc.), allergic diseases, infections (for example, human immunodeficiency virus infection, acquired immunodeficiency syndrome, etc.), psychoneurotic diseases, cerebral diseases, cardiovascular disease, metabolic diseases, and cancerous diseases (for example, cancer, cancer metastasis, etc.), or an agent for regeneration therapy.
COMPOUND CONTAINING BASIC GROUP AND USE THEREOF
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Page/Page column 183, (2008/06/13)
A compound represented by the general formula (I-0): (I-0) (wherein the symbols are as defined in the description), a salt thereof, N-oxide form thereof, or solvate thereof, or a prodrug of any of these; and a medicinal use of these. The compound has CXCR4 antagonistic activity and is hence useful, e.g., as a preventive and/or therapeutic agent for CXCR4-mediated diseases, e.g., inflammatory/immunologic diseases (e.g., articular rheumatism, arthritis, retinopathy, pulmonary fibrosis, and rejection reactions against transplanted organs), allergic diseases, infectious diseases (e.g., human immunodeficiency virus infection and acquired immunological deficiency syndrome), mental/nervous diseases, brain diseases, cardiac/vascular diseases, metabolic diseases, and carcinomatous diseases (e.g., cancers and cancer metastasis), or as an agent for regenerative medicine.
