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Usage

Uses

Used in Pharmaceutical Synthesis:
2-Chloro-5-fluoro-4-(methylsulfanyl)pyrimidine is used as a building block in the synthesis of pharmaceuticals for its potential to contribute to the development of new drugs. Its unique structure allows for the creation of diverse medicinal compounds with specific therapeutic properties.
Used in Agrochemical Production:
In the agrochemical industry, 2-Chloro-5-fluoro-4-(methylsulfanyl)pyrimidine serves as an essential intermediate in the production of various agrochemicals. Its incorporation aids in the development of effective pesticides and other agricultural chemicals that enhance crop protection and yield.
Used in Organic Synthesis:
2-Chloro-5-fluoro-4-(methylsulfanyl)pyrimidine is utilized as a reactive intermediate in organic synthesis. Its presence in chemical reactions can lead to the formation of a wide range of functional materials and organic compounds, expanding the scope of chemical research and product development.
Used in Chemical Industry for Functional Materials:
As a valuable intermediate, 2-Chloro-5-fluoro-4-(methylsulfanyl)pyrimidine plays a crucial role in the production of functional materials in the chemical industry. Its unique attributes enable the creation of materials with specific properties, such as reactivity, stability, or selectivity, which are essential for various industrial applications.

Upstream product

• 2927-71-1 2,4-dichloro-5-fluoropyrimidine 
• 5188-07-8 sodium thiomethoxide 

Relevant academic research and scientific papers

Optimization of 2,4-diamino-5-fluoropyrimidine derivatives as protein kinase C theta inhibitors with mitigated time-dependent drug-drug interactions and P-gp liability

Abstract Protein kinase C theta (PKCθ) plays a critical role in T cell signaling and has therapeutic potential for T cell-mediated diseases such as transplant rejection and rheumatoid arthritis. Here, a series of 2,4-diamino-5-fluoropyrimidine derivatives were prepared and evaluated for their inhibition of PKCθ. Of these compounds, 14f was found to exhibit potent PKCθ inhibitory activity and significantly weak CYP3A4 time-dependent inhibition (TDI) and P-glycoprotein (P-gp) liability.

[1,4]OXAZEPINO[2,3-C]QUI NOLI NONE DERIVATIVES AS BLC6 INHIBITORS

The present invention relates to compounds that function as inhibitors of BCL6 (B-cell lymphoma 6) activity. The present invention also relates to processes for the preparation of these compounds, to pharmaceutical compositions comprising them, and to their use in the treatment of proliferative disorders, such as cancer, as well as other diseases or conditions in which BCL6 activity is implicated.

PYRROLO[2,3-B]PYRIDIN DERIVATIVES AS INHIBITORS OF INFLUENZA VIRUS REPLICATION

Provided herein are compounds of Formula A, B or C that can inhibit the replication of influenza viruses, reduce the amount of influenza viruses, and/or treat influenza.

PYRIMIDINE AND PYRIDINE DERIVATIVES AND USE IN TREATMENT, AMELIORATION OR PREVENTION OF INFLUENZA THEREOF

Provided herein is a compound of formula (I), optionally in the form of a pharmaceutically acceptable salt, solvate, polymorph, prodrug, codrug, cocrystal, tautomer, racemate, enantiomer, or diastereomer or mixture thereof, which is useful in treating, ameliorating or preventing influenza.