877932-98-4Relevant academic research and scientific papers
Nonpeptide Renin Inhibitors Employing a Novel 3-Aza(or oxa)-2,4-dialkyl Glutaric Acid Moiety as a P2/P3 Amide Bond Replacement
Baker, William R.,Fung, Anthony K. L.,Kleinert, Hollis D.,Stein, Herman H.,Plattner, Jacob J.,et al.
, p. 1722 - 1734 (2007/10/02)
A new series of renin inhibitors has been developed.The inhibitors feature a novel replacement for the P2/P3 dipeptide moiety normally associated with renin inhibitors.The dipeptide replacement was a (2S,4S)-3-aza(or oxa)-2,4-dialkylglutaric acid amide.Ex
Decahydroisoquinoline carboxylic acids
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, (2008/06/13)
What are disclosed are aminoacid compounds of the formula STR1 wherein n is 0 or 1, and salts thereof, said compounds and salts having hypotensive properties; methods for making the compounds; pharmaceutical compositions containing the compounds or salts;
Process for preparing carboxyalkyl dipeptides
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, (2008/06/13)
Pharmaceutically active carboxyalkyl dipeptides such as enalapril, lisinopril and the like, are prepared from a starting amino acid such as L-alanine, by protecting the acid function of the amino acid with an alkyl silyl protecting group, while it is reacted with an α-halo ester, at its amino function. Subsequently, the silyl protectant is removed, and the acid group is reacted with the amino function of an appropriate amino acid such as L-proline, to form the dipeptide product.
Aromatic amino acid derivatives
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, (2008/06/13)
A compound having the formula: STR1 wherein n is 0-5, inclusive; R1 is H or the identifying group of an amino acid; and R2 is H, aralkyl, or alkyl.
