877932-98-4

Basic information

• Product Name: Benzenebutanoic acid, a-[[(1S)-1-carboxyethyl]amino]-, monoethyl ester
• CAS NO: 877932-98-4
• Molecular Formula: C15H21NO4
• Molecular Weight: 279.336
• Mol File: 877932-98-4.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: Benzenebutanoic acid, a-[[(1S)-1-carboxyethyl]amino]-, monoethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Benzenebutanoic acid, a-[[(1S)-1-carboxyethyl]amino]-, monoethyl ester(877932-98-4)
• EPA Substance Registry System: Benzenebutanoic acid, a-[[(1S)-1-carboxyethyl]amino]-, monoethyl ester(877932-98-4)

Safety Data

• Hazardous Substances Data: 877932-98-4(Hazardous Substances Data)

Upstream product

• 56-41-7 L-alanin 
• 82586-61-6 ethyl 2-bromo-4-phenylbutanoate 
• 64920-29-2 2-oxo-4-phenylbutanoic acid ethyl ester 
• 82717-95-1 (2S)-benzyl 3-aza-4-(ethoxycarbonyl)-2-methyl-6-phenylhexanoate 

Downstream Products

• 82009-36-7 N-[N-(1-(S)-ethoxycarbonyl-3-phenylpropyl)-L-alanyl]-L-proline 
• 76095-16-4 Amprace 
• 85441-61-8 quinapril 
• 130316-66-4 (2S)-3-aza-4-(ethoxycarbonyl)-2-methyl-6-phenylhexanamide of (2S,3R,4S)-2-amino-1-cyclohexyl-3,4-dihydroxy-6-methylheptane 

Relevant articles and documents

Process for the preparation of compounds having ACE inhibitory action and intermediates in said process

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Nonpeptide Renin Inhibitors Employing a Novel 3-Aza(or oxa)-2,4-dialkyl Glutaric Acid Moiety as a P2/P3 Amide Bond Replacement

A new series of renin inhibitors has been developed.The inhibitors feature a novel replacement for the P2/P3 dipeptide moiety normally associated with renin inhibitors.The dipeptide replacement was a (2S,4S)-3-aza(or oxa)-2,4-dialkylglutaric acid amide.Ex

Process for preparing carboxyalkyl dipeptides

Pharmaceutically active carboxyalkyl dipeptides such as enalapril, lisinopril and the like, are prepared from a starting amino acid such as L-alanine, by protecting the acid function of the amino acid with an alkyl silyl protecting group, while it is reacted with an α-halo ester, at its amino function. Subsequently, the silyl protectant is removed, and the acid group is reacted with the amino function of an appropriate amino acid such as L-proline, to form the dipeptide product.