82009-36-7Relevant academic research and scientific papers
Pulmonary delivery for bioconjugation
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, (2008/06/13)
Methods of and compositions for pulmonary delivery of therapeutic agents which are capable of forming covalent bonds with a site of interest or which have formed a covalent bond with a pulmonary solution protein are disclosed. Therapeutic agents useful in the invention include wound healing agents, antibiotics, anti-inflammatories, anti-oxidants, anti-proliferatives, immunosupressants, anti-infective and anti-cancer agents.
Process for preparing carboxyalkyl dipeptides
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, (2008/06/13)
Pharmaceutically active carboxyalkyl dipeptides such as enalapril, lisinopril and the like, are prepared from a starting amino acid such as L-alanine, by protecting the acid function of the amino acid with an alkyl silyl protecting group, while it is reacted with an α-halo ester, at its amino function. Subsequently, the silyl protectant is removed, and the acid group is reacted with the amino function of an appropriate amino acid such as L-proline, to form the dipeptide product.
Process for preparing carboxyalkyl dipeptides
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, (2008/06/13)
A process is disclosed for preparing carboxyalkyl dipeptides of the formula: STR1
ANTIHYPERTENSIVE COMPOSITION
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, (2008/06/13)
A pharmaceutical composition is disclosed which comprises the combination of interphenylene 9-thia-11-oxo-12-aza prostanoic acid derivatives and carboxyalkyl dipeptide derivatives.
AMINOACID DERIVATIVES AS ANTIHYPERTENSIVES
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, (2008/06/13)
The invention relates to new carboxyalkyl dipeptide derivatives and related compounds which are useful as antihypertensives.
