878005-35-7Relevant academic research and scientific papers
Dual inhibitors of thymidylate synthase and dihydrofolate reductase as antitumor agents: Design, synthesis, and biological evaluation of classical and nonclassical pyrrolo[2,3-d]pyrimidine antifolates
Gangjee, Aleem,Jain, Hiteshkumar D.,Phan, Jaclyn,Lin, Xin,Song, Xiaohong,McGuire, John J.,Kisliuk, Roy L.
, p. 1055 - 1065 (2007/10/03)
We designed and synthesized a classical analogue N-[4-[(2-amino-6-ethyl-3, 4-dihydro-4-oxo-7H-pyrrolo-[2,3-d]pyrimidin-5-yl)thio]benzoyl]-L-glutamic acid (4) and thirteen nonclassical analogues 5-17 as potential dual thymidylate synthase (TS) and dihydrof
