878005-50-6Relevant academic research and scientific papers
Synthesis and evaluation of some 2-[(substituted) ethanoyl]amino- 5-aryl-1,3,4-thiadiazoles as diuretic agents
Jain, Sanmati K.,Mishra, Pradeep
, p. 1305 - 1308 (2011/12/21)
Twelve 2-[(substituted)ethanoyl]amino-5-aryl-1,3,4-thiadiazoles were prepared by the reaction of 2-(chloro ethanoyl)amino-5-aryl-1,3,4- thiadiazoles and various secondary amines. These compounds were screened for diuretic activity. The compounds namely 4a1, 4b2 and 4c2 showed good diuretic activity comparable with the standard drug acetazolamide at a dose level of 100 mg/kg, orally in albino rats.
