833472-84-7

Usage

Uses

Used in Pharmaceutical Industry:
2,4-Dichloro-6-(4-fluorophenyl)pyrimidine is utilized as a key intermediate in the synthesis of various biologically active compounds, including antiviral and anticancer agents. Its unique structure and functional groups contribute to the development of potent therapeutic agents that target specific biological pathways.
Used in Insecticidal and Herbicidal Applications:
This chemical compound has been studied for its potential insecticidal and herbicidal properties, making it a candidate for use in agricultural and pest control industries. Its ability to target and control pests and weeds can contribute to more effective and sustainable agricultural practices.
Used in Biomedical Research:
2,4-Dichloro-6-(4-fluorophenyl)pyrimidine has been explored for its potential use as a fluorescent probe for nucleic acid detection. Its fluorescent properties allow for the visualization and analysis of nucleic acids in various research applications, contributing to advancements in molecular biology and diagnostics.

Upstream product

• 3764-01-0 2,4,6-trichloropyrimidine 
• 1765-93-1 4-fluoroboronic acid 
• 603-35-0 triphenylphosphine 
• 3934-20-1 2,6-Dichloropyrimidine 
• 460-00-4 1-Bromo-4-fluorobenzene 

Downstream Products

• 878199-72-5 4-chloro-6-(4-fluorophenyl)-2-(2-methylpyrrolidin-1-yl)pyrimidine 
• 1117922-90-3 2-chloro-4-(4-fluorophenyl)-6-(4-(1-methyl-1H-imidazol-2-yl)-piperazin-1-yl)-pyrimidine 
• 878809-85-9 (3R)-4-[2-chloro-6-(4-fluoro-phenyl)-pyrimidin-4-yl]-3-methyl-piperazine-1-carboxylic acid tert-butyl ester 
• 1580440-50-1 ethyl 1-(4-(4-fluorophenyl)-6-(2-methoxyethoxy)pyrimidin-2-yl)piperidine-4-carboxylate 
• 1580440-51-2 1-(4-(4-fluorophenyl)-6-(2-methoxyethoxy)pyrimidin-2-yl)piperidine-4-carboxylic acid 
• 1580440-48-7 2-chloro-4-(4-fluorophenyl)-6-(2-methoxyethoxy)pyrimidine 
• 878809-88-2 4-((R)-4-(5-bromo-3-methylpyridin-2-yl)-2-methylpiperazin-1-yl)-6-(4-fluorophenyl)-2-((R)-2-methylpyrrolidin-1-yl)pyrimidine 

Relevant academic research and scientific papers

IDH1 mutant micromolecule inhibitor, and preparation method and application thereof

The invention discloses an IDH1 mutant micromolecule inhibitor, and a preparation method and application thereof. The structure of the inhibitor is as shown in a formula I, and the definition of the substituent groups is as described in the specification

INHIBITORS OF INFLUENZA VIRUS REPLICATION, APPLICATION METHODS AND USES THEREOF

A class of compounds as inhibitors of influenza virus replication, preparation methods thereof, pharmaceutical compositions containing these compounds, and uses of these compounds and pharmaceutical compositions thereof in the treatment of influenza.

INHIBITORS OF INFLUENZA VIRUS REPLICATION, APPLICATION METHODS AND USES THEREOF

The invention provides a novel class of compounds as inhibitors of influenza virus replication, preparation methods thereof, pharmaceutical compositions containing these compounds, and uses of these compounds and pharmaceutical compositions thereof in the treatment of influenza.

Development of a Multikilogram Scale Synthesis of a TRPV1 Antagonist

A highly efficient, regioselective five-step synthesis of the TRPV1 antagonist 1 is described. The coupling of piperazine 7 with dichloropyrimidine 8 proceeded via a regioselective Pd-mediated amination affording product 11 in excellent yield. Conversion of the penultimate product 14 afforded 1 through formation of a magnesium ate complex and trapping with CO2.

NOVEL HETEROCYCLIC COMPOUNDS AS GATA MODULATORS

Novel heterocyclic compounds, sstereoisomers thereof and/or pharmaceutically acceptable salts of formula (I) and its stereoisomers are provided. Additionally, methods of forming novel heterocyclic compounds, stereoisomers thereof and/or pharmaceutically a

PYRIMIDINE, PYRIDINE AND TRIAZINE DERIVATIVES AS MAXI-K CHANNEL OPENERS.

A compound of formula (A); wherein ring A is an aromatic ring or a heteroaromatic ring; R1 is independently halogen, cyano, etc., each of X1, X2 and X3 is CR2 or nitrogen, R2 is independently hydrogen, etc., n is 0, 1, 2, 3 or 4; -D-Y is -O-CH2COOH, etc, and G is a substituted amino, a substituted heterocyclic group, etc, or a pharmaceutical acceptable salt thereof, has activities of opening BK channels.

NOVEL PYRIMIDINE COMPOUNDS, PROCESS FOR THEIR PREPARATION AND COMPOSITIONS CONTAINING THEM

The present invention provides new heterocyclic compounds, particularly substituted pyrimidines, methods and compositions for making and using these heterocyclic compounds, and methods for treating a variety of diseases and disease states, including atherosclerosis, arthritis, restenosis, diabetic nephropathy, or dyslipidemia, or disease states mediated by the low expression of Perlecan.

A highly regioselective amination of 6-aryl-2,4-dichloropyrimidine

A highly regioselective amination of 6-aryl-2,4-dichloropyrimidine with aliphatic secondary amines and aromatic amines has been developed which strongly favors the formation of the C4-substituted product. The reactions with aliphatic amines are carried ou

SUBSTITUTED BIARYL PIPERAZINYL-PYRIDINE ANALOGUES

Substituted biaryl piperazinyl-pyridine analogues are provided, of the Formula (I): wherein variables are as described herein. Such compounds are ligands that may be used to modulate specific receptor activity in vivo or in vitro,and are particularly useful in the treatment of conditions associated with pathological receptor activation in humans, domesticated companion animals and livestock animals. Pharmaceutical compositions and methods for using such compounds to treat such disorders are provided, as are methods for using such ligands for receptor localization studies.

HETEROARYL SUBSTITUTED PIPERAZINYL-PYRIDINE ANALOGUES

Substituted biaryl piperazinyl-pyridine analogues are provided, of the Formula: wherein variables are as described herein. Such compounds are ligands that may be used to modulate specific receptor activity in vivo or in vitro, and are particularly useful