878276-92-7Relevant academic research and scientific papers
A novel protocol for the one-pot borylation/Suzuki reaction provides easy access to hinge-binding groups for kinase inhibitors
Hooper,Zambon,Springer
, p. 963 - 969 (2016/01/15)
The one-pot borylation/Suzuki reaction is a very efficient means of accessing cross-coupling products of two aryl-halide partners that generally requires the use of specific catalysts or ligands and/or relatively long reaction times. This new microwave-assisted method provides a quick one-pot borylation/Suzuki reaction protocol that we applied to the synthesis of various bi- or poly-aryl scaffolds, including a variety of aryl and heteroaryl ring systems and the core frameworks of kinase inhibitors vemurafenib and GDC-0879.
4-Anilino-6-phenyl-quinoline inhibitors of mitogen activated protein kinase-activated protein kinase 2 (MK2)
Olsson, Henric,Sjoe, Peter,Ersoy, Oguz,Kristoffersson, Anna,Larsson, Joakim,Norden, Bo
scheme or table, p. 4738 - 4740 (2010/10/02)
A class of inhibitors of mitogen activated protein kinase-activated kinase 2 (MK2) was discovered via high-throughput screening. This compound class demonstrates activity against the enzyme with sub-μM IC50 values, and suppresses LPS-induced TN
Successive substitution of halogen atoms in 4,6-dihaloquinolines in palladium-catalyzed reactions with amines and arylboronic acids
Beletskaya,Tsvetkov,Tsvetkov,Latyshev,Lukashev
, p. 215 - 219 (2007/10/03)
A procedure was developed for the synthesis of 4,6-diamino- and 4,6- or 6,4-arylaminoquinolines by palladium-catalyzed C-N- and/or C-C-cross-coupling of 6-bromo-4-chloroquinoline.
The successive substitution of halogens in 4-chloro-6-iodoquinoline by aryl groups in cross-coupling reactions with arylboronic acids
Tsvetkov, Alexey V.,Latyshev, Gennadij V.,Lukashev, Nikolai V.,Beletskaya, Irina P.
, p. 7267 - 7270 (2007/10/03)
The conditions for selective stepwise substitution of iodine and chlorine atoms in 4-chloro-6-iodoquinoline which allow the synthesis of the corresponding diarylquinolines with different aryl groups in the 4- and 6-positions, in a one-pot procedure, in hi
