878277-24-8Relevant articles and documents
Ferrocene-mediated proton-coupled electron transfer in a series of ferrocifen-type breast-cancer drug candidates
Hillard, Elizabeth,Vessieres, Anne,Thouin, Laurent,Jaouen, Gerard,Amatore, Christian
, p. 285 - 290 (2006)
A double-barreled approach: The addition of ferrocene to an antiestrogen drug skeleton was found to induce cytotoxicity towards breast-cancer cells that are resistant to the common antiestrogen drug. The efficacy of this drug has been related to the proton-coupled electron transfer observed in the presence of pyridine as a base (see picture). (Chemical Equation Presented)
Synthesis, oxidation chemistry and cytotoxicity studies on ferrocene derivatives of diethylstilbestrol
Tan, Yong Leng Kelvin,Pigeon, Pascal,Hillard, Elizabeth A.,Top, Siden,Plamont, Marie-Aude,Vessieres, Anne,McGlinchey, Michael J.,Mueller-Bunz, Helge,Jaouen, Gerard
, p. 10871 - 10881 (2010/04/01)
A series of compounds is described in which one of the ethyl groups in diethylstilbestrol has been replaced by a ferrocenyl substituent. Only those derivatives incorporating phenol moieties underwent isomerisation from the Z to the E form, and some of the
