878287-77-5Relevant academic research and scientific papers
Synthesis and structure-activity relationships of 8-azabicyclo[3.2.1]octane benzylamine NK1 antagonists
Thomson, Christopher G.,Carlson, Emma,Chicchi, Gary G.,Kulagowski, Janusz J.,Kurtz, Marc M.,Swain, Christopher J.,Tsao, Kwei-Lan C.,Wheeldon, Alan
, p. 811 - 814 (2006)
A series of 8-azabicyclo[3.2.1]octane amine hNK1 antagonists has been investigated and structure-activity relationships of the benzylamine and 6-exo substituents described. Acidic substituents at C6 give a series of high affinity compounds for
