878398-49-3Relevant academic research and scientific papers
Route to pyrrolo[1,2-a]quinoxalines via a furan ring opening-pyrrole ring closure sequence
Nevolina, Tatyana A.,Skvortsov, Dmitry A.,Sorotskaja, Ludmila N.,Trushkov, Igor V.,Uchuskin, Maxim G.,Zelina, Elena Y.
, (2019/12/27)
A method was developed for the synthesis of pyrrolo[1,2-a]quinoxalines based on an acid-promoted furan ring opening of readily accessible N-(furan-2-ylmethyl)-2-nitroanilines or their heterocyclic analogues followed by a key reductive Paal-Knorr cyclization of the corresponding nitro-1,4-diketones.
Biological activity of modified and exchanged 2-amino-5-nitrothiazole amide analogues of nitazoxanide
Ballard, T. Eric,Wang, Xia,Olekhnovich, Igor,Koerner, Taylor,Seymour, Craig,Hoffman, Paul S.,MacDonald, Timothy L.
supporting information; experimental part, p. 3537 - 3539 (2010/08/22)
Head group analogues of the antibacterial and antiparasitic drug nitazoxanide (NTZ) are presented. A library of 39 analogues was synthesized and assayed for their ability to suppress growth of Helicobacter pylori, Campylobacter jejuni, Clostridium difficile and inhibit NTZ target pyruvate:ferredoxin oxidoreductase (PFOR). Two head groups assayed recapitulated NTZ activity and possessed improved activity over their 2-amino-5-nitrothiazole counterparts, demonstrating that head group modification is a viable route for the synthesis of NTZ-related antibacterial analogues.
Rapid synthesis of imidazo[4,5-b]pyridine containing polycyclics by means of palladium-catalyzed amidation of 2-chloro-3-nitropyridine
Salomé, Christophe,Schmitt, Martine,Bourguignon, Jean-Jacques
supporting information; experimental part, p. 3798 - 3800 (2009/10/11)
Regioselective nucleophilic substitution of 2-chloro 3-nitropyridine with heterocyclic amides under Pd-catalyzed reaction conditions as described by Buchwald yielded imidazo [4,5-b] pyridine-containing polycyclics as novel scaffolds.
PYRROLO[2,3-c]PYRIDINE DERIVATIVES AND PROCESSES FOR THE PREPARATION THEREOF
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Page/Page column 11, (2010/10/20)
The present invention provides novel pyrrolo[2,3-c]pyridine derivatives or pharmaceutically acceptable salts thereof, processes for the preparation thereof, and compositions comprising the same. The pyrrolo[2,3-c]pyridine derivatives or pharmaceutically acceptable salts thereof of the present invention have excellent proton pump inhibition effects and possess the ability to attain a reversible proton pump inhibitory effect.
