878556-91-3

Upstream product

• 467471-31-4 (+)-(2S,3R,S_S)-2-(benzylamino)-4-methyl-3-(p-tolylsulfinylamino)pentan-1-ol 
• 18162-48-6 tert-butyldimethylsilyl chloride 
• 878556-88-8 (+)-(1R,2S,S_S)-N-[2-benzylamino-3-(t-butyldimethylsilyloxy)-1-(i-propyl)prop-1-yl]-p-tolylsulfinamide 
• 79-04-9 chloroacetyl chloride 

Downstream Products

• 878556-99-1 (+)-(5R,6S)-1-benzyl-6-(t-butyldimethylsilyloxymethyl)-5-(i-propyl)-5,6-dihydro-1H-pyrazin-2-one 
• 878556-95-7 (+)-(5R,6S,S_S)-1-benzyl-6-[(t-butyldimethylsilyloxy)methyl]-5-(i-propyl)-4-(p-tolylsulfinyl)piperazin-2-one 

Relevant academic research and scientific papers

Highly diastereoselective Barbier allylation and iminium cyclization: a simple entry to bicyclic and tricyclic piperazinones

Barbier allylation of 5,6-dihydropyrazin-2(1H)-ones leads to a single isomer of 3-allylpiperazin-2-ones in high yields. Further Pictet-Spengler-Grieco cyclization of 3-allylpiperazin-2-ones with aldehydes provides bicyclic and tricyclic piperazinones with

Synthesis of highly substituted enantiopure piperazines and ketopiperazines from vicinal N-sulfinyl diamines

Enantiopure 1-benzyl-2,3-disubstituted piperazines (4) have been synthesized by treatment of N-sulfinyl-N-benzyldiamino alcohols (1) with diethyl oxalate and sodium methoxide followed by reduction with borane. Alternatively, the sulfinamido group was pres