87875-77-2

Upstream product

• 87875-78-3 1-methyl-4-pyridone hydrobromide salt 

Downstream Products

• 936635-76-6 N-(5-chloropyridin-2-yl)-3-hydroxy-2-{[4-(1-methyl-4-oxo-1,4-dihydropyridin-3-yl)benzoyl]amino}benzamide 
• 936635-85-7 4-(1-methyl-4-oxo-1,4-dihydropyridin-3-yl)benzoic acid 
• 936635-84-6 methyl 4-(1-methyl-4-oxo-1,4-dihydropyridin-3-yl)benzoate 

Relevant academic research and scientific papers

Kinetics and mechanism of the bromination of 4-pyridone and related derivatives in aqueous solution

The kinetics of bromination of 4-pyridone and selected derivatives have been measured in aqueous solutions in the pH range 0-9, at 25 deg C.The tautomeric system 4-pyridone 4-hydroxypyridine (1a 2a) reacts with bromine via the predominant (pyridone) tautomer at pH 6. 3-Bromo-4-pyridone behaves similary.The kinetics also reveal that the facile dibromination of 4-pyridone occurs because at most pH's the monobromo derivative is actually more reactive towards bromine by virtue of its lower pKa values.From the point of view of reactivity the 4-pyridones and their anions behave as substituted phenoxide ions. 4-Methoxypyridine does not undergo bromination under comparable conditions, but rather forms a complex with bromine.