87880-13-5Relevant academic research and scientific papers
A sequential one-pot approach to 1,2,4,5-tetrasubstituted-2H-imidazole synthesis from disubstituted alkynes
Boominathan, Siva Senthil Kumar,Chen, Chung-Yu,Huang, Po-Jui,Hou, Ruei-Jhih,Wang, Jeh-Jeng
, p. 6914 - 6918 (2015/09/02)
A sequential one-pot approach to the tetrasubstituted 2H-imidazole scaffolds has been developed from disubstituted alkynes and structurally diverse ketones. The reaction proceeds via a diketo intermediate generated from internal alkynes followed by the addition of ammonium acetate and a suitable ketone, affording a diverse range of 2H-imidazoles. Using air-moisture stable reaction conditions and inexpensive reagents, the transformation demonstrates a broad substrate scope and good functional group compatibility.
UNEXPECTED REACTIONS OF 1,4-DIAZA-1,3-DIENES UNDER ACYLATING CONDITIONS. A NEW CYCLIZATION TO NON-ACYLATED IMIDAZOLE DERIVATIVES
Armesto, Diego,Bosch, Paula,Horspool, William M.,Ortiz, Maria J.
, p. 4605 - 4608 (2007/10/02)
The reaction of anions from 1,2-bisimines with acid chlorides gives unacylated 2H-imidazoles.The unprecedented reactivity of these anions is interpreted by cyclization of the radical generated by electron transfer from the anion to the acid chloride.
Quaternary Salts of 2H-Imidazoles
Katritzky, Alan R.,Borja, Susana Bravo,Marquet, Jorge,Sammes, Michael P.
, p. 2065 - 2069 (2007/10/02)
Treatment of the 4,5-diphenyl-2H-imidazoles (1a-e) with alkyl iodides gives novel 1H+,2H-imidazolium salts (2) and (3).The metho-salt (2) N-methyl protons are readily exchanged for deuterium, and anions formed by the action of base give, with m
