878808-68-5Relevant academic research and scientific papers
Nucleophilic gem-difluoro(phenylsulfanyl)methylation of carbonyl compounds with PhSCF2H in the presence of a phosphazene as a base
Punirun, Teerachai,Soorukram, Darunee,Kuhakarn, Chutima,Reutrakul, Vichai,Pohmakotr, Manat
, p. 4162 - 4169 (2014/07/08)
Direct nucleophilic gem-difluoro(phenylsulfanyl)methylation of carbonyl compounds has been achieved by use of difluoro(phenylsulfanyl)methane (PhSCF2H) and the phosphazene base P4-tBu in THF. Non-enolizable aldehydes and ketones are suitable substrates to undergo nucleophilic gem-difluoro(phenylsulfanyl)methylation, providing α-gem-difluoromethylated adducts in good yields. In addition, this methodology is also applicable with cyclic imides and acid anhydrides. Direct nucleophilic gem-difluoro(phenylsulfanyl)methylation of aromatic aldehydes and ketones, cyclic imides, and acid anhydrides with difluoro(phenylsulfanyl)methane (PhSCF2H) reagent was achieved in the presence of the phosphazene P4-tBu as a base. The corresponding adducts should be useful for further synthetic conversion into a variety of fluorinated compounds. Copyright
Nucleophilic difluoro(phenylsulfonyl)methylation of carbonyls with PhSO2CF2H reagent in the presence of in situ generated substoichiometric amount of base Dedicated to Professor Iwao Ojima on the occasion of his receipt of the ACS Aw
Hu, Mingyou,Gao, Bing,Ni, Chuanfa,Zhang, Laijun,Hu, Jinbo
, p. 52 - 58 (2013/10/01)
The reactions between carbonyl compounds and PhSO2CF 2H using substoichiometric amount of base in situ generated from N(TMS)3 and catalytic amount of Me4NF have been investigated. It is found that both enolizabl
Difluoro(phenylchalcogen)methylation of aldehydes, ketones, and imines with S-, Se-, and Te-containing reagents PhXCF2H (X = S, Se, Te)
Hu, Mingyou,Wang, Fei,Zhao, Yanchuan,He, Zhengbiao,Zhang, Wei,Hu, Jinbo
experimental part, p. 45 - 58 (2012/03/27)
A series of sulfur-, selenium- and tellurium-containing (phenylchalcogen)difluoromethylation reagents PhSCF2H (1a), PhSeCF2H (1b), and PhTeCF2H (1c) were prepared, and their relative reactivity towards aldehydes, ketones,
α,α-Difluoro-α-phenylsulfanylmethyl carbanion equivalent: a novel gem-difluoromethylenation of carbonyl compounds
Pohmakotr, Manat,Boonkitpattarakul, Kanhokthron,Ieawsuwan, Winai,Jarussophon, Suwatchai,Duangdee, Nongnaphat,Tuchinda, Patoomratana,Reutrakul, Vichai
, p. 5973 - 5985 (2007/10/03)
α,α-Difluoro-α-phenylsulfanyl-α-trimethylsilylmethane (PhSCF2SiMe3) has been demonstrated as an α,α-difluoro-α-phenylsulfanylmethyl carbanion equivalent. gem-Difluorophenylsulfanylmethylation of carbonyl compounds has been successful
Fluoride-induced nucleophilic (phenylthio)difluoromethylation of carbonyl compounds with [difluoro(phenylthio)methyl]trimethylsilane (TMS-CF 2SPh)
Prakash, G.K. Surya,Hu, Jinbo,Wang, Ying,Olah, George A.
, p. 529 - 534 (2007/10/03)
A fluoride-induced nucleophilic (phenylthio)difluoromethylation method using TMS-CF2SPh has been achieved. This new methodology efficiently transfers "PhSCF2" group into both enolizable and non-enolizable aldehydes and ketones to giv
