879-15-2

Basic information

• Product Name: 1(2H)-Naphthalenone,2-diazo-
• CAS NO: 879-15-2
• Molecular Weight: 170.17
• Mol File: 879-15-2.mol

Chemical Properties

• CAS DataBase Reference: 1(2H)-Naphthalenone,2-diazo- (CAS DataBase Reference)
• NIST Chemistry Reference: 1(2H)-Naphthalenone,2-diazo- (879-15-2)
• EPA Substance Registry System: 1(2H)-Naphthalenone,2-diazo- (879-15-2)

Safety Data

• Hazardous Substances Data: 879-15-2(Hazardous Substances Data)

Usage

Uses

Used in Organic Synthesis:
1(2H)-Naphthalenone,2-diazois used as a reagent in organic synthesis for the introduction of the diazo group into other organic compounds. The diazo group is a versatile functional group that can undergo a variety of chemical transformations, making 1(2H)-Naphthalenone,2-diazo- a valuable intermediate.
Used in Pharmaceutical Synthesis:
In the pharmaceutical industry, 1(2H)-Naphthalenone,2-diazois used as a key intermediate in the synthesis of various pharmaceuticals. Its ability to introduce the diazo group into organic compounds facilitates the creation of new drug molecules with potential therapeutic applications.
Used in Agrochemical Synthesis:
Similarly, in the agrochemical industry, 1(2H)-Naphthalenone,2-diazois utilized as an intermediate in the synthesis of agrochemicals. The diazo group's reactivity allows for the development of new compounds with pesticidal or herbicidal properties, contributing to agricultural productivity and crop protection.
Used in Fine Chemicals Synthesis:
1(2H)-Naphthalenone,2-diazois also employed in the synthesis of fine chemicals, where its reactivity and the versatility of the diazo group are leveraged to produce specialty chemicals for various applications, including fragrances, dyes, and other high-value products.
Due to the reactivity and potentially hazardous nature of 1(2H)-Naphthalenone,2-diazo-, it must be handled with care and used in a controlled manner to ensure safety and effectiveness in its applications.

Upstream product

• 68432-16-6 1(2H)-naphthalenone 
• 135-19-3 β-naphthol 
• 90-15-3 α-naphthol 
• 524-42-5 1,2-naphthoquinone 
• 7732-18-5 water 
• 606-41-7 2-amino-1-naphthol 
• 7758-99-8 copper(II) sulfate 
• 41772-23-0 1-hydroxy-2-naphthylamine hydrochloride 
• 4323-69-7 [1]naphthyl-nitro-amine 

Downstream Products

• 90-15-3 α-naphthol 
• 39891-79-7 methyl 1H-indene-3-carboxylate 
• 1888-41-1 2-methoxy-1-naphthol 
• 51056-37-2 ethyl 1H-indene-3-carboxylate 
• 73733-01-4 2-Ethoxy-1-naphthol 
• 14209-41-7 3H-indene-1-carboxylic acid 
• 76939-81-6 1-(benzyloxy)-2-bromonaphthalene 
• 20686-65-1 2-methyloxazolo<4,5-a>naphthalene 
• 6336-79-4 1,2-naphthalenediol diacetate 
• 574-00-5 1,2-Dihydroxynaphthalene 
• 60433-62-7 2-phenylnaphthalen-1-ol 
• 581-80-6 4,4'-bis(trifluoromethyl)biphenyl 
• 1292303-42-4 C₁₇H₁₁F₃O 
• 1292303-41-3 C₁₇H₁₄O₂ 

Relevant articles and documents

Rh(II)-catalyzed formal [3+3] cycloaddition of diazonaphthoquinones and propargyl alcohols: Synthesis of 2,3-dihydronaphtho-1,4-dioxin derivatives

A Rh(II)-catalyzed formal [3+3] cyclization of diazonaphthoquinones and propargyl alcohol is reported to afford 2,3-dihydro-1,4-benzodioxins. Various terminal propargyl alcohols react with diazonapthoquinone in the presence of Rh2(OAc)4/s

ELECTROPHILIC AZIDIZING AGENT OR DIAZOTIZING AGENT

PROBLEM TO BE SOLVED: To provide a novel electrophilic azidizing agent that is safe without explosibility, capable of azidizing a nucleophilic compound in an electrophilic manner. SOLUTION: The present invention provides an azide imidazolium derivative re

A 'sulfonyl-azide-free' (SAFE) aqueous-phase diazo transfer reaction for parallel and diversity-oriented synthesis

Diazo transfer reactions are notoriously associated with the use of potentially explosive sulfonyl azides. The first 'sulfonyl-azide-free' (SAFE) protocol for producing diazo compounds from their active-methylene precursors via the Regitz diazo transfer reaction was developed and has displayed a remarkable substrate scope. It can be applied to generating arrays of diazo compounds for further evolution via combinatorial chemistry and a range of scaffold-generating transformations.

Rh(iii)-Catalyzed straightforward arylation of 8-methyl/formylquinolines using diazo compounds

A straightforward Rh(iii)-catalyzed general strategy was developed for the introduction of naphthol/phenol moieties to the C(sp3)-H bond of 8-methylquinoline using diazonaphthalen-2(1H)-ones/quinone diazides. The developed method was further extended towards the arylation of 8-formylquinolines to accomplish diarylketone derivatives. The method is simple, relatively rapid, and chemo and regioselective with a wide scope and functional group tolerance. The synthetic utility was established through gram-scale synthesis and biologically active molecule construction.

Ir(III)-catalyzed direct C-H functionalization of arylphosphine oxides: A strategy for MOP-type ligands synthesis

Diazo compounds as coupling partners are efficiently applied to Ir(III)-catalyzed direct C-H functionalization of arylphos-phine oxides. Involving C-H activation, carbene insertion, and tautomerism, this reaction proceeds under mild conditions, thus proving an approach to the synthesis of MOP-type ligand precursor in a single step. The utility of this transformation has been further demonstrated in ligand synthesis as well as in the construction of phosphole framework.

Synthesis of diazonaphthoquinones from naphthols by diazo-transfer reaction

Various orthodiazonaphthoquinones (1-diazo-2(1H)-naphthalenones and 2-diazo-1(2H)-naphthalenones) were synthesized using the diazo-transfer reaction between the appropriate naphthol and 2-azido-1,3-dimethylimidazolinium chloride (ADMC). The ADMC was prepa

3-Naphthylindole Construction by Rhodium(II)-Catalyzed Regioselective Direct Arylation of Indoles with 1-Diazonaphthalen-2-(1H)-ones

The regioselective direct 3-arylation of indoles with 1-diazonaphthalen-2-(1H)-ones was developed by means of a rhodium(II) pivalate-catalyzed cross-coupling reaction. This procedure provided a variety of novel 3-naphthylindoles in high yield. The direct coupling of benzofuran, pyrrole or furan with 1-diazonaphthalen-2-(1H)-ones afforded 2- or 3-naphthyl substituted heterocycles.

Pd(OAc)2-catalyzed macrocyclization of 1,2-diazonaphthoquinones with cyclic ethers

Pd(OAc)2 was found to be an efficient catalyst for the macrocyclization of 1,2-diazonaphthoquinones and cyclic ethers. This transformation serves as an efficient method for the synthesis of protected 1,2-naphthalenediols.

Synthesis of 1,2-naphthalenediol diacetates by rhodium(II)-catalyzed reaction of 1,2-diazonaphthoquinones with acetic anhydride

A metal-catalyzed reaction of α-diazocarbonyl compounds with an acid anhydride is reported. In particular, 1,2-naphthalenediol diacetates were synthesized by the reaction of 1,2-diazonaphthoquinones with acetic anhydride catalyzed by Rh2(OAc)s

Synthesis of diazonaphthoquinones from naphthols by diazo-transfer reaction with 2-azido-1,3-dimethylimidazolinium chloride

An efficient synthetic method for the synthesis of diazonaphthoquinones from naphthols is described. A variety of diazonaphthoquinones were synthesized from the corresponding naphthols by the diazo transfer with 2-azido-1,3- dimethylimidazolinium chloride prepared by the reaction of 2-chloro-1,3- dimethylimidazorinium chloride and sodium azide. Georg Thieme Verlag Stuttgart New York.