879-39-0

Usage

Uses

Used in Environmental Monitoring:
2,3,4,5-Tetrachloronitrobenzene is used as a marker for environmental contamination, as its presence indicates the presence of toxic substances in habitats for various mammals. Monitoring its levels can help assess the health of ecosystems and the potential risks to wildlife.
Used in Research and Development:
2,3,4,5-Tetrachloronitrobenzene can be used as a research compound in the development of methods for detecting and mitigating environmental contamination. Studying its properties and effects can contribute to a better understanding of the impacts of toxic substances on ecosystems and the organisms that inhabit them.

Reactivity Profile

2,3,4,5-Tetrachloronitrobenzene will behave as a weak oxidizer, and will react with strong reducing agents including hydrides, sulfides and nitrides.

Purification Methods

Crystallise it from aqueous EtOH. [Beilstein 5 II 187, 5 III 617, 5 IV 728.]

InChI:InChI=1/C6HCl4NO2/c7-2-1-3(11(12)13)5(9)6(10)4(2)8/h1H

Upstream product

• 634-66-2 1,2,3,4,-tetrachlorobenzene 
• 634-67-3 2,3,4-trichloroaniline 
• 17700-09-3 4-nitro-1,2,3-trichlorobenzene 
• 87-61-6 1,2,3-trichlorobenzene 
• 38411-17-5 2,5-dchloro-4-nitroacetanilide 
• 6627-34-5 2,5-dichloro-4-nitroaniline 
• 611-06-3 2,4-dichloronitrobenzene 
• 172215-92-8 2,3,4-trichloro-6-nitrobenzenamine 
• 62406-69-3 2,3,6-trichloro-4-nitro-aniline 

Downstream Products

• 2691-93-2 2,3,4,5-Tetrachlorofluorobenzene 
• 15952-70-2 2,4-difluoro-3,5-dichloro-nitrobenzene 
• 733802-71-6 C₁₆H₁₄Cl₃NO₄ 
• 654-36-4 2,3,4,6-tetrachloroaniline 
• 634-83-3 2,3,4,5-tetrachloroaniline 
• 781-15-7 1,2,3,4-tetrachloro-5,6-dinitrobenzene 

Relevant academic research and scientific papers

Preparation method of anagrelide derivative

The invention discloses a preparation method of an anagrelide derivative, and belongs to the field of pharmaceutical synthesis. The method is reasonable in process design, high in operability, relatively mild in reaction condition and high in yield, and can realize industrial production. According to the preparation method of the anagrelide derivative, synthesis of the anagrelide derivative is realized by taking 1,2,3,4-tetrachlorobenzene as a raw material through six-step reaction. The anagrelide derivative prepared through the preparation method provides an important basis for scientific evaluation of the quality, the safety and the efficacy of anagrelide; furthermore, the anagrelide derivative is high in pharmacological activity, can be prepared into drugs for treating thrombocytosis caused by various reasons, and has an important application value.

Preparation method for 3,5,-dichloro-2,4,-difluoroaniline

The invention relates to the field of organic synthesis, specifically to a preparation method for 3,5,-dichloro-2,4,-difluoroaniline and application thereof. The preparation method for 3,5,-dichloro-2,4,-difluoroaniline provided by the invention comprises the following steps: 1) nitration reaction; 2) reduction reaction; 3) diazotization reaction; 4) nitration reaction; 5) fluorination reaction; and 6) reduction reaction. The preparation method for 3,5,-dichloro-2,4,-difluoroaniline provided by the invention has the following beneficial effects: 1) the method has mild reaction conditions, is stable and controllable, has less active sites, is insusceptible to side reaction, and has good yield and quality in the whole line; and 2) raw materials are cheap and easily available, so cost can be effectively reduced, and energy is saved; meanwhile, the use of chlorine gas is avoided, so the method is environment-friendly.

Process for preparing a quinolone-carboxylic acid

The present invention provides a process for preparing quinolonecarboxylic acid derivatives having the formula (I): wherein R1 is H, halogen, or amino; R2 is halogen; R3 is H, halogen, C1-4 alkoxyl, or CN; R4 is selected from the group consisting of C3-6cycloalkyl, C1-4alkyl, C1-4alkoxyC1-4alkyl, and C1-4alkylaminoC1-4alkyl. The invention also provides new acetophenones having the formula (II) that are intermediates for preparing the compound of the formula (I).

Ozone-mediated reaction of polychlorobenzenes and some related halogeno compounds with nitrogen dioxide: A novel non-acid methodology for the selective mononitration of moderately deactivated aromatic systems

In the presence of ozone and preferably methanesulfonic acid as catalyst, polychlorobenzenes undergo selective mononitration with nitrogen dioxide at low temperatures, giving the corresponding polychloronitrobenzenes, in most cases in nearly quantitative yields.

Electrophilic Aromatic Substitution. Part 33. Kinetics and Products of Aromatic Nitrations in Solutions of Dinitrogen Pentaoxide in Nitric Acid

The kinetics and/or products of reaction, in nitric acid containing 0-5 mol dm-3 of dinitrogen pentaoxide, of phenyltrimethylammonium perchlorate, 1,2-dichloro-4-nitrobenzene, 2,4-dinitrotoluene, 1,4-dichloro-2-nitrobenzene, 1,2,4-trichloro-5-nitrobenzene, 1,2,4,5-tetrachlorobenzene, pentachlorobenzene, 1,2,3-trichlorobenzene, 1,3,5-trichloro-2-nitrobenzene, 1,2-dichloro-3-nitrobenzene, 1,2,3,4-tetrachlorobenzene, and 1,3-dichloro-2-nitrobenzene, have been studied.For each substrate investigated kinetically, rate coefficients for nitration in solutions containing more than ca. 2 mol dm-3 dinitrogen pentaoxide increase more quickly than the concentration of nitronium ion.In the cases of 1,2,4,5-tetrachlorobenzene, 1,4-dichloro-2-nitrobenzene, and 1,2,4-trichloro-5-nitrobenzene, but not with the other substrates, there was evidence for the formation of, in addition to expected aromatic nitroproducts, unstable cyclohexadiene products.Those from 1,2,4-trichloro-5-nitrobenzene were identified as a diastereomeric pair of 3,5,6-trichloro-2,4-dinitrocyclohexa-2,5-dienyl nitrates.A mechanism for the formation of these products is proposed.