879-39-0

Basic information

• Product Name: 2,3,4,5-Tetrachloronitrobenzene
• Synonyms: ML AS THE BASE);ML IN MEOH (1000UG;1,2,3,4-tetrachloro-5-nitro-benzen;1,2,3,4-Tetrachloro-5-nitrobenzene;1-Nitro-2,3,4,5-tetrachlorobenzene;2,3,4,5-Tetrachloro-1-nitrobenzene;5-nitro-1,2,3,4-tetrachloro-benzen;Benzene, 5-nitro-1,2,3,4-tetrachloro-
• CAS NO: 879-39-0
• Molecular Formula: C₆HCl₄NO₂
• Molecular Weight: 260.89
• EINECS: 212-906-5
• Product Categories: Alpha sort;Pesticides&Metabolites;Q-ZAlphabetic;TA - TE
• Mol File: 879-39-0.mol
• Article Data: 6

Chemical Properties

• Melting Point: 65°C
• Boiling Point: 120.5°C (rough estimate)
• Flash Point: 144.4oC
• Appearance: /
• Density: 1.9820 (rough estimate)
• Vapor Pressure: 0.000822mmHg at 25°C
• Refractive Index: 1.6200 (estimate)
• Storage Temp.: -20°C Freezer, Under inert atmosphere
• Solubility: Chloroform (Slightly), Methanol (Slightly)
• Water Solubility: 7.305mg/L(20 oC)
• CAS DataBase Reference: 2,3,4,5-Tetrachloronitrobenzene(CAS DataBase Reference)
• NIST Chemistry Reference: 2,3,4,5-Tetrachloronitrobenzene(879-39-0)
• EPA Substance Registry System: 2,3,4,5-Tetrachloronitrobenzene(879-39-0)

Safety Data

• Hazard Codes: Xn
• Statements: 20/21/22-36/37/38
• Safety Statements: 26-36/37/39-36
• RTECS: DB9625000
• Hazardous Substances Data: 879-39-0(Hazardous Substances Data)

Usage

Uses

1,2,3,4-Tetrachloro-5-nitrobenzene is a toxic contaminant of environmental habitats for various mammals.

Reactivity Profile

2,3,4,5-Tetrachloronitrobenzene will behave as a weak oxidizer, and will react with strong reducing agents including hydrides, sulfides and nitrides.

Purification Methods

Crystallise it from aqueous EtOH. [Beilstein 5 II 187, 5 III 617, 5 IV 728.]

InChI:InChI=1/C6HCl4NO2/c7-2-1-3(11(12)13)5(9)6(10)4(2)8/h1H

Upstream product

• 62406-69-3 2,3,6-trichloro-4-nitro-aniline 
• 611-06-3 2,4-dichloronitrobenzene 
• 38411-17-5 2,5-dchloro-4-nitroacetanilide 
• 634-67-3 2,3,4-trichloroaniline 
• 17700-09-3 4-nitro-1,2,3-trichlorobenzene 
• 87-61-6 1,2,3-trichlorobenzene 
• 634-66-2 1,2,3,4,-tetrachlorobenzene 
• 6627-34-5 2,5-dichloro-4-nitroaniline 
• 172215-92-8 2,3,4-trichloro-6-nitrobenzenamine 

Downstream Products

• 15952-70-2 2,4-difluoro-3,5-dichloro-nitrobenzene 
• 733802-71-6 C₁₆H₁₄Cl₃NO₄ 
• 2691-93-2 2,3,4,5-Tetrachlorofluorobenzene 
• 654-36-4 2,3,4,6-tetrachloroaniline 
• 634-83-3 2,3,4,5-tetrachloroaniline 
• 781-15-7 1,2,3,4-tetrachloro-5,6-dinitrobenzene 

Relevant articles and documents

Preparation method of anagrelide derivative

The invention discloses a preparation method of an anagrelide derivative, and belongs to the field of pharmaceutical synthesis. The method is reasonable in process design, high in operability, relatively mild in reaction condition and high in yield, and can realize industrial production. According to the preparation method of the anagrelide derivative, synthesis of the anagrelide derivative is realized by taking 1,2,3,4-tetrachlorobenzene as a raw material through six-step reaction. The anagrelide derivative prepared through the preparation method provides an important basis for scientific evaluation of the quality, the safety and the efficacy of anagrelide; furthermore, the anagrelide derivative is high in pharmacological activity, can be prepared into drugs for treating thrombocytosis caused by various reasons, and has an important application value.

Process for preparing a quinolone-carboxylic acid

The present invention provides a process for preparing quinolonecarboxylic acid derivatives having the formula (I): wherein R1 is H, halogen, or amino; R2 is halogen; R3 is H, halogen, C1-4 alkoxyl, or CN; R4 is selected from the group consisting of C3-6cycloalkyl, C1-4alkyl, C1-4alkoxyC1-4alkyl, and C1-4alkylaminoC1-4alkyl. The invention also provides new acetophenones having the formula (II) that are intermediates for preparing the compound of the formula (I).

Electrophilic Aromatic Substitution. Part 33. Kinetics and Products of Aromatic Nitrations in Solutions of Dinitrogen Pentaoxide in Nitric Acid

The kinetics and/or products of reaction, in nitric acid containing 0-5 mol dm-3 of dinitrogen pentaoxide, of phenyltrimethylammonium perchlorate, 1,2-dichloro-4-nitrobenzene, 2,4-dinitrotoluene, 1,4-dichloro-2-nitrobenzene, 1,2,4-trichloro-5-nitrobenzene, 1,2,4,5-tetrachlorobenzene, pentachlorobenzene, 1,2,3-trichlorobenzene, 1,3,5-trichloro-2-nitrobenzene, 1,2-dichloro-3-nitrobenzene, 1,2,3,4-tetrachlorobenzene, and 1,3-dichloro-2-nitrobenzene, have been studied.For each substrate investigated kinetically, rate coefficients for nitration in solutions containing more than ca. 2 mol dm-3 dinitrogen pentaoxide increase more quickly than the concentration of nitronium ion.In the cases of 1,2,4,5-tetrachlorobenzene, 1,4-dichloro-2-nitrobenzene, and 1,2,4-trichloro-5-nitrobenzene, but not with the other substrates, there was evidence for the formation of, in addition to expected aromatic nitroproducts, unstable cyclohexadiene products.Those from 1,2,4-trichloro-5-nitrobenzene were identified as a diastereomeric pair of 3,5,6-trichloro-2,4-dinitrocyclohexa-2,5-dienyl nitrates.A mechanism for the formation of these products is proposed.