879088-84-3

Upstream product

• 46004-37-9 methyl 4-amino-2-chlorobenzoate 
• 13324-11-3 methyl 2-chloro-4-nitrobenzoate 
• 99-60-5 2-chloro-4-nitrobenzoic acid 
• 1190947-66-0 methyl 2-chloro-4-(ethoxycarbonothioylthio)benzoate 
• 67-56-1 methanol 
• 116209-31-5 2-chloro-4-mercaptobenzoic acid 

Downstream Products

• 1190947-67-1 methyl 2-chloro-4-(2-hydroxy-2-methylpropylthio)benzoate 

Relevant academic research and scientific papers

PIPERIDINE DERIVATIVES AS LIVER X RECEPTOR β AGONISTS, COMPOSITIONS, AND THEIR USE

Piperidine compounds of the Formular: (I) and pharmaceutically acceptable salts thereof, wherein X, Y, R 1, R 2, R 3, L, R 4, L 1, Q and R 5 are as defined herein. The compounds and pharmaceutically acceptable compositions comprising a compound thereof, are useful as Liver X-β receptor (LXRβ) agonists, and may be useful for treating or preventing pathologies related thereto. Such pathologies include, but are not limited to, inflammatory diseases and diseases characterized by defects in cholesterol and lipid metabolism, such as Alzheimer's disease.

PYRIDYL INHIBITORS OF HEDGEHOG SIGNALLING

The invention provides novel inhibitors of hedgehog signaling that are useful as s therapeutic agent for treating malignancies where the compounds have the general formula (I): where A, X, Y R1, R2, R3, R4, m and n are as described herein.

Pyridyl inhibitors of hedgehog signalling

The invention provides novel inhibitors of hedgehog signaling that are useful as a therapeutic agents for treating malignancies where the compounds have the general formula I: wherein A, X, Y R1, R2, R3, R4, m and n are as described herein.