879098-89-2

Upstream product

• 60410-16-4 (1R,4S)-4-hydroxy-2-cyclopentene-1-yl acetate 
• 879098-68-7 Acetic acid (3aR,4S,5R,6aS)-4-[4-(1-benzyloxy-hexyl)-phenyl]-2-oxo-hexahydro-cyclopenta[b]furan-5-yl ester 
• 879098-65-4 Acetic acid (1R,4S)-4-(1-butoxy-2-iodo-ethoxy)-cyclopent-2-enyl ester 

Downstream Products

• 148436-63-9 AH 13205 
• 879098-92-7 (Z)-7-{(1R,2S)-2-[4-(1-Benzyloxy-hexyl)-phenyl]-5-oxo-cyclopentyl}-hept-5-enoic acid 
• 879098-70-1 (Z)-7-{(1R,2S,5S)-2-[4-(1-Benzyloxy-hexyl)-phenyl]-5-hydroxy-cyclopentyl}-hept-5-enoic acid 
• 879098-91-6 (3aR,4S,6aS)-4-[4-(1-Benzyloxy-hexyl)-phenyl]-hexahydro-cyclopenta[b]furan-2-ol 
• 879098-69-8 (3aR,4S,6aS)-4-[4-(1-Benzyloxy-hexyl)-phenyl]-hexahydro-cyclopenta[b]furan-2-one 
• 879098-90-5 thiocarbonic acid O-{4-[4-(1-benzyloxy-hexyl)-phenyl]-2-oxo-hexahydro-cyclopenta[b]furan-5-yl} ester O-phenyl ester 

Relevant academic research and scientific papers

Cobalt(diamine)-catalyzed cross-coupling reaction of alkyl halides with arylmagnesium reagents: Stereoselective constructions of arylated asymmetric carbons and application to total synthesis of AH13205

A cobalt-diamine complex catalyzes the cross-coupling reactions of primary and secondary alkyl halides with aryl Grignard reagents. It is confirmed that oxidative addition of alkyl halide to cobalt proceeds via a radical process. Optically pure Ueno-Stork halo acetals undergo diastereoselective cross-coupling reactions, the products of which are transformed into optically active THF derivatives. A sequential radical cyclization/arylation reaction under cobalt catalysis provides extremely short access to a synthetic prostaglandin AH13205.