879129-24-5

Upstream product

• 95-54-5 1,2-diamino-benzene 
• 879283-41-7 3-(2-aminophenyl)-4,5-dimethylthiazole-2(3H)-thione 

Downstream Products

• 1421265-41-9 C₁₇H₁₅N₃OS₂ 
• 879129-26-7 3-(2-isothiocyanatophenyl)-4-methylthiazole-2(3H)-one 
• 1421265-46-4 C₁₈H₁₄F₃N₃O₂S 
• 1421265-47-5 C₁₉H₁₃F₆N₃O₂S 
• 1421265-45-3 C₁₇H₁₅N₃O₂S 

Relevant academic research and scientific papers

Novel phenyl(thio)ureas bearing (thio)oxothiazoline group as potential BACE-1 inhibitors: Synthesis and biological evaluation

We report the synthesis and the β-site amyloid precursor protein cleaving enzyme-1 inhibitory properties of novel phenyl(thio)ureas bearing 2-(thio)oxothiazoline derivatives. A library of analogues was prepared according to specific synthetic schemes and the inhibitory activity was monitored using a fluorescence resonance energy transfer assay. Several analogues show potent inhibitory activities ranging between 1 and 0.01 μM and the activity is related to the NH acidity of the (thio)urea motif. Our results illustrate once again the close relationship between molecular recognition, complexation of the active site in enzymatic system, and organocatalysis utilizing explicit hydrogen bonding.