879283-41-7

Upstream product

• 4091-39-8 3-chloro-2-butanone 
• 95-54-5 1,2-diamino-benzene 

Downstream Products

• 1421265-39-5 C₁₉H₁₆F₃N₃S₃ 
• 1421265-40-8 C₂₀H₁₅F₆N₃S₃ 
• 1421265-41-9 C₁₇H₁₅N₃OS₂ 
• 879129-24-5 3-(2-aminophenyl)-4-methylthiazol-2(3H)-one 
• 1421265-45-3 C₁₇H₁₅N₃O₂S 
• 1421265-46-4 C₁₈H₁₄F₃N₃O₂S 
• 1421265-47-5 C₁₉H₁₃F₆N₃O₂S 
• 879129-26-7 3-(2-isothiocyanatophenyl)-4-methylthiazole-2(3H)-one 
• 199381-24-3 C₁₆H₁₆N₂S₂Se₂ 
• 199381-21-0 C₁₆H₁₆N₂S₄ 
• 215809-15-7 3-(2-isothiocyanatophenyl)-4,5-dimethylthiazole-2(3H)-thione 

Relevant academic research and scientific papers

Novel phenyl(thio)ureas bearing (thio)oxothiazoline group as potential BACE-1 inhibitors: Synthesis and biological evaluation

We report the synthesis and the β-site amyloid precursor protein cleaving enzyme-1 inhibitory properties of novel phenyl(thio)ureas bearing 2-(thio)oxothiazoline derivatives. A library of analogues was prepared according to specific synthetic schemes and the inhibitory activity was monitored using a fluorescence resonance energy transfer assay. Several analogues show potent inhibitory activities ranging between 1 and 0.01 μM and the activity is related to the NH acidity of the (thio)urea motif. Our results illustrate once again the close relationship between molecular recognition, complexation of the active site in enzymatic system, and organocatalysis utilizing explicit hydrogen bonding.

New route to 3-alkylthiazolo[3,2-a]benzimidazole derivatives

3-Alkyl-thiazolo[3,2-a]benzimidazole derivatives are obtained in high yields via the corresponding 4-alkyl-N-3-(2-aminophenyl)-thiazoline-2-thiones which are easily prepared from 1,2-diaminobenzene, CS2 and halogenoketones. This new route compares advantageously with the classical mercaptobenzimidazole routes in term of simplicity, isolated yields and availability of the starting materials.

Towards functionalised quasi-planar dithiadiazafulvalenes: Synthesis of various precursors

The synthesis of 1,2-bis(2-thioxo-2,3-dihydrothiazol-3-yl)benzenes and 1,2-bis(2-selenoxo-2,3-dihydrothiazol-3-yl)benzenes precursors of quasi- planar dithiadiazafulvalenes, is described. Functionalisation of these derivatives via lithiation is also reported.