879132-47-5

Basic information

• Product Name: 3,3-dibroMo-1-((2-(triMethylsilyl)ethoxy)Methyl)-1H-pyrrolo[2,3-b]pyridin-2(3H)-one
• Synonyms: 3,3-dibroMo-1-((2-(triMethylsilyl)ethoxy)Methyl)-1H-pyrrolo[2,3-b]pyridin-2(3H)-one;2H-Pyrrolo[2,3-b]pyridin-2-one, 3,3-dibroMo-1,3-dihydro-1-[[2-(triMethylsilyl)ethoxy]Methyl]-
• CAS NO: 879132-47-5
• Molecular Formula: C₁₃H₁₈Br₂N₂O₂Si
• Molecular Weight: 422.18772
• Mol File: 879132-47-5.mol
• Article Data: 33

Chemical Properties

• Boiling Point: 456.9±45.0 °C(Predicted)
• Appearance: /
• Density: 1.551±0.06 g/cm3(Predicted)
• Storage Temp.: 2-8°C
• PKA: 0.24±0.40(Predicted)
• CAS DataBase Reference: 3,3-dibroMo-1-((2-(triMethylsilyl)ethoxy)Methyl)-1H-pyrrolo[2,3-b]pyridin-2(3H)-one(CAS DataBase Reference)
• NIST Chemistry Reference: 3,3-dibroMo-1-((2-(triMethylsilyl)ethoxy)Methyl)-1H-pyrrolo[2,3-b]pyridin-2(3H)-one(879132-47-5)
• EPA Substance Registry System: 3,3-dibroMo-1-((2-(triMethylsilyl)ethoxy)Methyl)-1H-pyrrolo[2,3-b]pyridin-2(3H)-one(879132-47-5)

Safety Data

• Hazardous Substances Data: 879132-47-5(Hazardous Substances Data)

Usage

Description

3,3-dibromo-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-pyrrolo[2,3-b]pyridin-2(3H)-one is a chemical compound belonging to the pyrrolopyridine family, characterized by its molecular formula C12H16Br2NOSi. 3,3-dibromo-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-pyrrolo[2,3-b]pyridin-2(3H)-one features a unique structure that includes bromine, nitrogen, oxygen, and silicon atoms, making it a valuable intermediate in organic synthesis and medicinal chemistry research.

Uses

Used in Organic Synthesis:
3,3-dibromo-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-pyrrolo[2,3-b]pyridin-2(3H)-one is used as a building block in organic synthesis for the preparation of various bioactive molecules. Its unique reactivity and structural features contribute to the development of new chemical compounds with potential applications in different fields.
Used in Medicinal Chemistry Research:
In the field of medicinal chemistry, 3,3-dibromo-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-pyrrolo[2,3-b]pyridin-2(3H)-one serves as a key intermediate for the synthesis of pharmaceutical drugs. Its presence in the molecular structure can enhance the therapeutic properties of the resulting compounds, making it a valuable tool in drug discovery and development.
Used in Pharmaceutical Drug Development:
3,3-dibromo-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-pyrrolo[2,3-b]pyridin-2(3H)-one is utilized in the development of new pharmaceutical drugs due to its potential therapeutic applications. The incorporation of this compound into drug molecules can lead to the discovery of novel treatments for various diseases and medical conditions.
Used in Chemical Synthesis Industry:
3,3-dibromo-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-pyrrolo[2,3-b]pyridin-2(3H)-one is used as a versatile tool in the chemical synthesis industry. The presence of the trimethylsilyl group enhances its stability and compatibility with other reaction conditions, making it suitable for a wide range of chemical reactions and processes.

Upstream product

• 76513-69-4 (2-trimethylethylsilylethoxy)methyl chloride 
• 271-63-6 7-Azaindole 
• 879132-46-4 1-((2-(trimethylsilyl)ethoxy)methyl)-1H-pyrrolo[2,3-b]pyridine 

Downstream Products

• 1059185-34-0 2-[5-(3,5-difluorophenyl)-3-ethyl-5-methyl-2,4-dioxoimidazolidin-1-yl]-N-[(2R)-2'-oxo-1,1',2',3-tetrahydrospiro[indene-2,3'-pyrrolo[2,3-b]pyridin]-5-yl]acetamide 
• 1033608-31-9 tert-butyl (+/-)-(2'-oxo-1'-{[2-(trimethylsilyl)ethoxy]methyl}-1,1',2',3-tetrahydrospiro[indene-2,3'-pyrrolo[2,3-b]pyridin]-5-yl)carbamate 
• 957121-34-5 tert-butyl (R)-(2'-oxo-1'-{[2-(trimethylsilyl)ethoxy]methyl}-1,1',2',3-tetrahydrospiro[indene-2,3'-pyrrolo[2,3-b]pyridin]-5-yl)carbamate 
• 957121-35-6 tert-butyl (S)-(2'-oxo-1'-{[2-(trimethylsilyl)ethoxy]methyl}-1,1',2',3-tetrahydrospiro[indene-2,3'-pyrrolo[2,3-b]pyridin]-5-yl)carbamate 
• 957130-49-3 (R)-5-amino-1,3-dihydrospiro[indene-2,3’-pyrrolo[2,3-b]pyridin]-2’(1’H)-one 
• 879132-50-0 5-amino-1‘-((2-(trimethylsilyl)ethoxy)methyl)-1,3-dihydrospiro[indene-2,3’-pyrrolo[2,3-b]pyridin]-2’(1’H)-one 
• 879132-49-7 5-nitro-1‘-((2-(trimethylsilyl)ethoxy)methyl)-1,3-dihydrospiro[indene-2,3’-pyrrolo[2,3-b]pyridin]-2’(1’H)-one 
• 1416438-78-2 spiro[cyclopropane-1,3'-pyrrolo[2,3-b]pyridin]-2'(1'H)-one 
• 884049-52-9 spiro[piperidine-4,3'-pyrrolo[2,3-b]pyridin]-2'(1'H)-one 
• 879132-48-6 1-((2-(trimethylsilyl)ethoxy)methyl)-1H-pyrrolo[2,3-b]pyridin-2(3H)-one 
• 1189569-43-4 (2R)-5-(2-{[(8R)-8-(3,5-difluorophenyl)-8-methyl-10-oxo-6,9-diazaspiro[4,5]dec-9-yl]methyl}cyclopropyl)-1,3-dihydrospiro[indene-2,3'-pyrrolo[2,3-b]pyridin]-2'(1'H)-one trifluoroacetate salt 
• 1189570-34-0 tert-butyl (8R)-8-(3,5-difluorophenyl)-8-methyl-10-oxo-9-[(2E)-3-(2'-oxo-1'-{[2-(trimethylsilyl)ethoxy]methyl}-1,1',2',3-tetrahydrospiro[indene-2,3'-pyrrolo[2,3-b]pyridin]-5-yl)prop-2-en-1-yl]-6,9-diazaspiro[4,5]decane-6-carboxylate 

Relevant articles and documents

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HETEROCYCLIC SPIRO-COMPOUNDS AS AM2 RECEPTOR INHIBITORS

Disclosed are compounds of the formula (I) and pharmaceutically acceptable salts thereof: wherein R1, R2, R4, R5, R6, R7, R8, R9, R10,Z, X1, X2, X3, L2, HET, n and q are as defined herein. The compounds are inhibitors of adrenomedullin receptor subtype 2 (AM2). Also disclosed are the compounds for use in the treatment of diseases modulated AM2, including proliferative diseases such as cancer; pharmaceutical compositions comprising the compounds; methods for preparing the compounds; and intermediates useful in the preparation of the compounds.

COMPOUNDS

Disclosed are compounds of the formula (I) and pharmaceutically acceptable salts thereof: (I) wherein R1, R2, R3, R4, R5, R6, R8, R9, X, X1, X2, X3, L1 and n are as defined herein. The compounds are inhibitors of adrenomedullin receptor subtype 2 (AM2). Also disclosed are the compounds for use in the treatment of diseases modulated AM2, including proliferative diseases such as cancer; pharmaceutical compositions comprising the compounds; methods for preparing the compounds;and intermediates useful in the preparation of the compounds.