879220-71-0Relevant academic research and scientific papers
Unequivocal synthesis of (Z)-alkene and (E)-fluoroalkene dipeptide isosteres to probe structural requirements of the peptide transporter PEPT1
Niida, Ayumu,Tomita, Kenji,Mizumoto, Makiko,Tanigaki, Hiroaki,Terada, Tomohiro,Oishi, Shinya,Otaka, Akira,Inui, Ken-Ichi,Fujii, Nobutaka
, p. 613 - 616 (2006)
Described is a novel synthetic route for dipeptide isosteres containing (Z)-alkene and (E)-fluoroalkene units as cis-amide bond equivalents via organocopper-mediated reduction of γ-acetoxy- or γ,γ-difluoro- α,β-unsaturated-δ-lactams. The synthesized isost
